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CRTC3 Recombinant Rabbit Monoclonal Antibody [JE63-18] (HA721887)

Price: Regular price $385.00

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Catalog# HA721887

Rabbit Monoclonal to CRTC3

Tested for

  • WB

  • IHC-P

  • FC

Reacts with

  • Human

  • Mouse

  • Rat

  • Monkey

Recombinant production enables lot-to-lot consistency and is animal-cruelty-free

Specifications

Product Type

Recombinant Rabbit monoclonal primary

Product Name

CRTC3 Recombinant Rabbit Monoclonal Antibody [JE63-18] (HA721887)

Immunogen

Synthetic peptide within human crtc3 aa 570-219 / 619.

Host

Rabbit

Positive Control

HeLa cell lysate, TT cell lysate, Jurkat cell lysate, HDLM-2 cell lysate, HEK-293 cell lysate, COS-1 cell lysate, RAW264.7 cell lysate, NIH/3T3 cell lysate, PC-12 cell lysate, C6 cell lysate, human brain tissue, human hodgkin lymphoma tissue, human lung tissue, human tonsil tissue, TT, RAW264.7, PC-12.

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

JE63-18

RRID

AB_3096768

APPLICATION DILUTION

  • WB

  • 1:2,000

  • IHC-P

  • 1:500

  • FC

  • 1:1,000

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Protein A affinity purified.

Molecular Weight

Predicted band size: 67 kDa

Isotype

IgG

TARGET

UNIPROT #

Q6UUV7

PROTEIN NAME

CRTC3

SYNONYMS

CREB regulated transcription coactivator 3 antibody;CREB-regulated transcription coactivator 3 antibody;CRTC 3 antibody;CRTC3 antibody;CRTC3_HUMAN antibody;FLJ21868 antibody;TORC 3 antibody;TORC-3 antibody;TORC3 antibody;Transducer of CREB protein 3 antibody;Transducer of regulated cAMP response element binding protein (CREB) 3 antibody;Transducer of regulated cAMP response element binding protein 3 antibody;Transducer of regulated cAMP response element-binding protein 3 antibody;Transducer of regulated CREB protein 3 antibody

SUBCELLULAR LOCATION

Nucleus, Cytoplasm.

FUNCTION

Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).

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