ICAM2 Recombinant Rabbit Monoclonal Antibody [JE63-28] (HA721893)

UNIPROT #

P35330

PROTEIN NAME

ICAM2

SYNONYMS

CD102 antibody;CD102 antigen antibody;ICAM 2 antibody;ICAM-2 antibody;Icam2 antibody;ICAM2_HUMAN antibody;Intercellular adhesion molecule 2 antibody;Ly60 antibody

SUBCELLULAR LOCATION

Membrane.

FUNCTION

The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance. Several transcript variants encoding the same protein have been found for this gene. ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.