UBE3A Recombinant Rabbit Monoclonal Antibody [JE32-48] (HA721921)

UNIPROT #

Q05086

PROTEIN NAME

UBE3A

SYNONYMS

ANCR antibody;Angelman syndrome antibody;AS antibody;CTCL tumor antigen se37 2 antibody;CTCL tumor antigen se37-2 antibody;E6 AP antibody;E6AP antibody;E6AP ubiquitin protein ligase antibody;E6AP ubiquitin-protein ligase antibody;EPVE6AP antibody;FLJ26981 antibody;HECT-type ubiquitin transferase E3A antibody;HPVE6A antibody;Human papilloma virus E6 associated protein Angelman syndrome antibody;Human papilloma virus E6 associated protein antibody;Human papillomavirus E6-associated protein antibody;NY REN 54 antigen antibody;Oncogenic protein associated protein E6 AP antibody;Oncogenic protein associated protein E6AP antibody;Oncogenic protein-associated protein E6-AP antibody;Renal carcinoma antigen NY REN 54 antibody;Renal carcinoma antigen NY-REN-54 antibody;UBE 3A antibody;Ube3a antibody;UBE3A protein antibody;UBE3A_HUMAN antibody;Ubiquitin protein ligase E3A antibody;Ubiquitin-protein ligase E3A antibody

SUBCELLULAR LOCATION

Nucleus. Cytoplasm.

FUNCTION

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. Several substrates have been identified including the RAD23A and RAD23B, MCM7 (which is involved in DNA replication), annexin A1, the PML tumor suppressor, and the cell cycle regulator CDKN1B. Catalyzes the high-risk human papilloma virus E6-mediated ubiquitination of p53/TP53, contributing to the neoplastic progression of cells infected by these viruses. Additionally, may function as a cellular quality control ubiquitin ligase by helping the degradation of the cytoplasmic misfolded proteins. Finally, UBE3A also promotes its own degradation in vivo. Plays an important role in the regulation of the circadian clock: involved in the ubiquitination of the core clock component ARNTL/BMAL1, leading to its proteasomal degradation.