HLA Class II DRB1 Recombinant Rabbit Monoclonal Antibody [JE60-43] (HA721927)

UNIPROT #

P01911

PROTEIN NAME

HLA Class II DRB1

SYNONYMS

2B1F_HUMAN antibody;DR1 antibody;DR16 antibody;DR5 antibody;DR8 antibody;DRB1 antibody;DRw10 antibody;DW2.2/DR2.2 antibody;FLJ75017 antibody;FLJ76359 antibody;HLA class II antigen beta chain antibody;HLA class II histocompatibility antigen, DR-1 beta chain antibody;HLA class II histocompatibility antigen, DRB1-15 beta chain antibody;HLA-DR-beta 1 antibody;HLA-DR1B antibody;HLA-DRB antibody;HLA-DRB1 antibody;human leucocyte antigen DRB1 antibody;Leucocyte antigen DR beta 1 chain antibody;leucocyte antigen DRB1 antibody;lymphocyte antigen DRB1 antibody;major histocompatibility complex, class II, DR beta 1 antibody;MHC class II antigen antibody;MHC class II antigen DRB1*15 antibody;MHC class II antigen HLA-DR13 antibody;MHC class II HLA-DR beta 1 chain antibody;MHC class II HLA-DR-beta cell surface glycoprotein antibody;MHC class II HLA-DRw10-beta antibody;SS1 antibody

SUBCELLULAR LOCATION

Cell membrane. Endoplasmic reticulum.

FUNCTION

A beta chain of antigen-presenting major histocompatibility complex class II (MHCII) molecule. In complex with the alpha chain HLA-DRA, displays antigenic peptides on professional antigen presenting cells (APCs) for recognition by alpha-beta T cell receptor (TCR) on HLA-DRB1-restricted CD4-positive T cells. This guides antigen-specific T-helper effector functions, both antibody-mediated immune response and macrophage activation, to ultimately eliminate the infectious agents and transformed cells. Typically presents extracellular peptide antigens of 10 to 30 amino acids that arise from proteolysis of endocytosed antigens in lysosomes. In the tumor microenvironment, presents antigenic peptides that are primarily generated in tumor-resident APCs likely via phagocytosis of apoptotic tumor cells or macropinocytosis of secreted tumor proteins. Presents peptides derived from intracellular proteins that are trapped in autolysosomes after macroautophagy, a mechanism especially relevant for T cell selection in the thymus and central immune tolerance. The selection of the immunodominant epitopes follows two processing modes: 'bind first, cut/trim later' for pathogen-derived antigenic peptides and 'cut first, bind later' for autoantigens/self-peptides. The anchor residue at position 1 of the peptide N-terminus, usually a large hydrophobic residue, is essential for high affinity interaction with MHCII molecules.