RAB10 Recombinant Rabbit Monoclonal Antibody [PSH03-24]

Function

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane. Regulates, for instance, SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane (By similarity). In parallel, it regulates the transport of TLR4, a toll-like receptor to the plasma membrane and therefore may be important for innate immune response (By similarity). Also plays a specific role in asymmetric protein transport to the plasma membrane. In neurons, it is involved in axonogenesis through regulation of vesicular membrane trafficking toward the axonal plasma membrane (By similarity). In epithelial cells, it regulates transport from the Golgi to the basolateral membrane. May play a role in the basolateral recycling pathway and in phagosome maturation (By similarity). May play a role in endoplasmic reticulum dynamics and morphology controlling tubulation along microtubules and tubules fusion. Together with LRRK2, RAB8A, and RILPL1, it regulates ciliogenesis. When phosphorylated by LRRK2 on Thr-73, binds RILPL1 and inhibits ciliogenesis.

Background References

1. Kluss JH et al. Lysosomal positioning regulates Rab10 phosphorylation at LRRK2+ lysosomes. Proc Natl Acad Sci U S A. 2022 Oct

2. Liu Z et al. LRRK2 and Rab10 coordinate macropinocytosis to mediate immunological responses in phagocytes. EMBO J. 2020 Oct

Subcellular Location

Cytoplasmic vesicle membrane.

UNIPROT

SwissProt: P61026 Human

SwissProt: P61027 Mouse

SwissProt: P35281 Rat

Synonyms

GTP binding protein RAB10 antibody

Rab10 antibody

RAB10 member RAS oncogene family antibody

RAB10_HUMAN antibody

Ras related GTP binding protein antibody

Ras related GTP binding protein RAB10 antibody

Ras-related protein Rab-10 antibody