EIF2S1 Recombinant Rabbit Monoclonal Antibody [PSH04-29] (HA722112)

UNIPROT #

P05198

PROTEIN NAME

EIF2S1

SYNONYMS

EIF 2 alpha antibody;EIF 2 antibody;EIF 2A antibody;EIF 2alpha antibody;eIF-2-alpha antibody;eIF-2A antibody;EIF-2alpha antibody;EIF2 alpha antibody;EIF2 antibody;EIF2A antibody;EIF2S1 antibody;Eukaryotic translation initiation factor 2 subunit 1 alpha 35kDa antibody;Eukaryotic translation initiation factor 2 subunit 1 alpha antibody;Eukaryotic translation initiation factor 2 subunit 1 antibody;Eukaryotic translation initiation factor 2 subunit alpha antibody;IF2A_HUMAN antibody

SUBCELLULAR LOCATION

Cytoplasm, Stress granule.

FUNCTION

Eukaryotic translation initiation factor 2 subunit 1 (eIF2α) is a protein that in humans is encoded by the EIF2S1 gene. The protein encoded by this gene is the alpha (α) subunit of the translation initiation factor eIF2 protein complex which catalyzes an early regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA (Met-tRNAiMet) to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, eIF2, and GTP. eIF2 is composed of 3 nonidentical subunits, alpha (α, 36 kD, this article), beta (β, 38 kD), and gamma (γ, 52 kD). The rate of formation of the ternary complex is modulated by the phosphorylation state of eIF2α. Phosphorylation of eIF2α by EIF-2 kinases plays a key role in regulating the integrated stress response.