EEA1 Recombinant Rabbit Monoclonal Antibody [JE59-34] (HA722147)

UNIPROT #

Q15075

PROTEIN NAME

EEA1

SYNONYMS

Early endosome antigen 1 antibody;Early endosome antigen 1, 162kD antibody;Early endosome associated protein antibody;EEA 1 antibody;EEA1 antibody;EEA1_HUMAN antibody;Endosome associated protein p162 antibody;Endosome-associated protein p162 antibody;MST105 antibody;MSTP105 antibody;ZFYVE2 antibody;Zinc finger FYVE domain containing protein 2 antibody;Zinc finger FYVE domain-containing protein 2 antibody

SUBCELLULAR LOCATION

Cytoplasm, Early endosome membrane.

FUNCTION

The gene EEA1 encodes for the 1400 amino acid protein, Early Endosome Antigen 1. EEA1 localizes exclusively to early endosomes and has an important role in endosomal trafficking. EEA1 binds directly to the phospholipid phosphatidylinositol 3-phosphate through its C-terminal FYVE domain and forms a homodimer through a coiled coil. EEA1 acts as a tethering molecule that couples vesicle docking with SNAREs such as N-ethylmaleimide sensitive fusion protein, bringing the endosomes physically closer and ultimately resulting in the fusion and delivery of endosomal cargo. EEA1 is a RAB5A effector protein which binds via an N-terminal zinc finger domain and is required for fusion of early and late endosomes and for sorting at the early endosome level. EEA1 plays a role in endocytosis and is recruited by Rab5-GTP to endosomal membranes. EEA1 may be regulated through monoubiquination, affecting endosome fusion and trafficking. Ubiquitin selective segregase p97 may regulate EEA1's tethering ability, affecting its endosome trafficking and morphplogy.