GRP78 / BIP Recombinant Rabbit Monoclonal Antibody [JE01-35] (HA722202)

UNIPROT #

P11021

PROTEIN NAME

GRP78 / BIP

SYNONYMS

78 kDa glucose regulated protein antibody;78 kDa glucose-regulated protein antibody;AL022860 antibody;AU019543 antibody;BIP antibody;D2Wsu141e antibody;D2Wsu17e antibody;Endoplasmic reticulum lumenal Ca(2+)-binding protein grp78 antibody;Endoplasmic reticulum lumenal Ca2+ binding protein grp78 antibody;Epididymis secretory sperm binding protein Li 89n antibody;FLJ26106 antibody;Glucose Regulated Protein 78 antibody;Glucose Regulated Protein 78kDa antibody;GRP 78 antibody;GRP-78 antibody;GRP78 antibody;GRP78_HUMAN antibody;Heat shock 70 kDa protein 5 antibody;Heat Shock 70kDa Protein 5 antibody;Heat shock protein family A (Hsp70) member 5 antibody;HEL S 89n antibody;Hsce70 antibody;HSPA 5 antibody;HSPA5 antibody;Immunoglobulin Heavy Chain Binding Protein antibody;Immunoglobulin heavy chain-binding protein antibody;mBiP antibody;MIF2 antibody;Sez7 antibody

SUBCELLULAR LOCATION

Endoplasmic reticulum lumen, Melanosome, Cytoplasm, Cell surface.

FUNCTION

Binding immunoglobulin protein (BiPS) also known as 78 kDa glucose-regulated protein (GRP-78) or heat shock 70 kDa protein 5 (HSPA5) is a protein that in humans is encoded by the HSPA5 gene. BiP is a HSP70 molecular chaperone located in the lumen of the endoplasmic reticulum (ER) that binds newly synthesized proteins as they are translocated into the ER, and maintains them in a state competent for subsequent folding and oligomerization. BiP is also an essential component of the translocation machinery and plays a role in retrograde transport across the ER membrane of aberrant proteins destined for degradation by the proteasome. BiP is an abundant protein under all growth conditions, but its synthesis is markedly induced under conditions that lead to the accumulation of unfolded polypeptides in the ER.