CRYAA Recombinant Rabbit Monoclonal Antibody [JE35-23] (HA722306)

UNIPROT #

P24622

PROTEIN NAME

CRYAA

SYNONYMS

Acry 1 antibody;Alpha crystallin A chain antibody;Alpha-crystallin A chain antibody;CRYA 1 antibody;CRYA1 antibody;CRYAA antibody;CRYAA_HUMAN antibody;Crystallin alpha 1 antibody;Crystallin alpha A antibody;Heat shock protein beta 4 antibody;Heat shock protein beta-4 antibody;HSPB 4 antibody;HspB4 antibody;short form antibody;Zonular Central Nuclear Cataract antibody

SUBCELLULAR LOCATION

Cytoplasm, Nucleus.

FUNCTION

Alpha-crystallin A chain is a protein that in humans is encoded by the CRYAA gene. Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (sHSP also known as the HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates.