SESN1 Recombinant Rabbit Monoclonal Antibody [JE36-66] (HA722307)

UNIPROT #

Q9Y6P5

PROTEIN NAME

SESN1

SYNONYMS

1110002G11Rik antibody;AU044290 antibody;MGC118148 antibody;MGC138241 antibody;MGC142129 antibody;OTTMUSP00000022799 antibody;p53 activated gene 26 antibody;p53 regulated PA26 nuclear protein antibody;p53 regulated protein PA26 antibody;p53-regulated protein PA26 antibody;PA26 antibody;RP11-787I22.1 antibody;sesn1 antibody;SESN1_HUMAN antibody;SEST1 antibody;sestrin 1 antibody;Sestrin-1 antibody

SUBCELLULAR LOCATION

Nucleus, Cytoplasm.

FUNCTION

Sestrin 1, also known as p53-regulated protein PA26, is a protein that in humans is encoded by the SESN1 gene. This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.