FABP1 is a human gene coding for the protein product FABP1 (Fatty Acid-Binding Protein 1). It is also frequently known as liver-type fatty acid-binding protein (LFABP). FABP1 is primarily expressed in the liver where it is involved in the binding, transport and metabolism of long-chain fatty acids (LCFAs), endocannabinoids, phytocannabinoids (and less so for synthetic cannabinoid receptor (CBR) agonists and antagonists) and other hydrophobic molecules. Altered expression of the protein has been linked to metabolic conditions including obesity.
Background References
1. Wilnes B et al. Urinary L-FABP as an Early Biomarker for Pediatric Acute Kidney Injury Following Cardiac Surgery with Cardiopulmonary Bypass: A Systematic Review and Meta-Analysis. Int J Mol Sci. 2024 Apr
2. Kalamutova A et al. L-FABP as a Potential Biomolecular Marker of Liver Graft Injury. J Clin Med. 2025 Oct
Western blot analysis of liver FABP on different lysates with Rabbit anti-liver FABP antibody (HA722321) at 1/1,000 dilution.
Lane 1: Human liver tissue lysate Lane 2: Mouse liver tissue lysate
Lysates/proteins at 40 µg/Lane.
Predicted band size: 14 kDa Observed band size: 8 kDa
Exposure time: 1 minute 16 seconds; ECL: K1801;
4-20% SDS-PAGE gel.
Proteins were transferred to a PVDF membrane and blocked with 5% NFDM/TBST for 1 hour at room temperature. The primary antibody (HA722321) at 1/1,000 dilution was used in 5% NFDM/TBST at 4℃ overnight. Goat Anti-Rabbit IgG - HRP Secondary Antibody (HA1001) at 1/50,000 dilution was used for 1 hour at room temperature.
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