RAP1GAP Recombinant Rabbit Monoclonal Antibody [JE41-74]

Function

This gene encodes a type of GTPase-activating-protein (GAP) that down-regulates the activity of the ras-related RAP1 protein. RAP1 acts as a molecular switch by cycling between an inactive GDP-bound form and an active GTP-bound form. The product of this gene, RAP1GAP, promotes the hydrolysis of bound GTP and hence returns RAP1 to the inactive state whereas other proteins, guanine nucleotide exchange factors (GEFs), act as RAP1 activators by facilitating the conversion of RAP1 from the GDP- to the GTP-bound form. In general, ras subfamily proteins, such as RAP1, play key roles in receptor-linked signaling pathways that control cell growth and differentiation. RAP1 plays a role in diverse processes such as cell proliferation, adhesion, differentiation, and embryogenesis. Alternative splicing results in multiple transcript variants encoding distinct proteins.

Background References

1. Shan T et al. Rap1GAP exacerbates myocardial infarction by regulating the AMPK/SIRT1/NF-kappaB signaling pathway. Cell Signal. 2024 May

2. Gao Y et al. Rap1GAP Mediates Angiotensin II-Induced Cardiomyocyte Hypertrophy by Inhibiting Autophagy and Increasing Oxidative Stress. Oxid Med Cell Longev. 2021 Apr

Subcellular Location

Golgi apparatus membrane.

UNIPROT

SwissProt: P47736 Human

SwissProt: A2ALS5 Mouse

Entrez Gene: 313644 Rat

Synonyms