Myf5 Recombinant Rabbit Monoclonal Antibody [JE38-56]

Function

Myogenic factor 5 is a protein that in humans is encoded by the MYF5 gene. It is a protein with a key role in regulating muscle differentiation or myogenesis, specifically the development of skeletal muscle. Myf5 belongs to a family of proteins known as myogenic regulatory factors (MRFs). These basic helix loop helix transcription factors act sequentially in myogenic differentiation. MRF family members include Myf5, MyoD (Myf3), myogenin, and MRF4 (Myf6). This transcription factor is the earliest of all MRFs to be expressed in the embryo, where it is only markedly expressed for a few days (specifically around 8 days post-somite formation and lasting until day 14 post-somite in mice). It functions during that time to commit myogenic precursor cells to become skeletal muscle. In fact, its expression in proliferating myoblasts has led to its classification as a determination factor. Furthermore, Myf5 is a master regulator of muscle development, possessing the ability to induce a muscle phenotype upon its forced expression in fibroblastic cells.

Background References

1. Maeng G et al. Humanized skeletal muscle in MYF5/MYOD/MYF6-null pig embryos. Nat Biomed Eng. 2021 Aug

2. Dong L et al. miR-9-5p promotes myogenic differentiation via the Dlx3/Myf5 axis. PeerJ. 2022 May

Subcellular Location

Nucleus.

UNIPROT

SwissProt: P24699 Mouse

Entrez Gene: 299766 Rat

Synonyms

bHLHc2 antibody

Class C basic helix loop helix protein 2 antibody

Class C basic helix-loop-helix protein 2 antibody

Myf 5 antibody

Myf-5 antibody

Myf5 antibody

MYF5_HUMAN antibody

Myogenic factor 5 antibody