GSC Recombinant Rabbit Monoclonal Antibody [JE51-35]

Function

Regulates chordin (CHRD). May play a role in spatial programing within discrete embryonic fields or lineage compartments during organogenesis. In concert with NKX3-2, plays a role in defining the structural components of the middle ear; required for the development of the entire tympanic ring. Probably involved in the regulatory networks that define neural crest cell fate specification and determine mesoderm cell lineages in mammals. This gene encodes a member of the bicoid subfamily of the paired (PRD) homeobox family of proteins. The encoded protein acts as a transcription factor and may be autoregulatory. A similar protein in mice plays a role in craniofacial and rib cage development during embryogenesis.

Background References

1. Parry D.A., Logan C.V., Stegmann A.P., Abdelhamed Z.A., Calder A., Khan S., Bonthron D.T., Clowes V., Sheridan E., Johnson C.A. SAMS, a syndrome of short stature, auditory-canal atresia, mandibular hypoplasia, and skeletal abnormalities is a unique neurocristopathy caused by mutations in Goosecoid. Am. J. Hum. Genet. 93:1135-1142 (2013)

Subcellular Location

Nucleus.

UNIPROT

SwissProt: P56915 Human

Entrez Gene: 317715 Rat

Synonyms

Goosecoid antibody

goosecoid homeobox antibody

GSC antibody

GSC_HUMAN antibody

Homeobox protein goosecoid antibody