MAP3K4 Recombinant Rabbit Monoclonal Antibody [JE62-99] (HA722466)

UNIPROT #

Q9Y6R4

PROTEIN NAME

MAP3K4

SYNONYMS

dJ473J16.1 (mitogen-activated protein kinase kinase kinase 4) antibody;FLJ42439 antibody;KIAA0213 antibody;M3K4_HUMAN antibody;MAP three kinase 1 antibody;MAP/ERK kinase kinase 4 antibody;MAP3K4 antibody;MAPK/ERK kinase kinase 4 antibody;MAPKKK4 antibody;MEK kinase 4 antibody;MEKK 4 antibody;MEKK4 antibody;Mitogen-activated protein kinase kinase kinase 4 antibody;MTK1 antibody;predicted protein of HQ0412 antibody;PRO0412 antibody;RP3-473J16.4 antibody;SSK2/SSK22 MAP kinase kinase kinase, yeast, homolog of antibody

SUBCELLULAR LOCATION

Cytoplasm.

FUNCTION

The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which then activates a specific MAPK. While the ERK MAPKs are activated by mitogenic stimulation, the CSBP2 and JNK MAPKs are activated by environmental stresses such as osmotic shock, UV irradiation, wound stress, and inflammatory factors. This gene encodes a MAPKKK, the MEKK4 protein, also called MTK1. This protein contains a protein kinase catalytic domain at the C terminus. The N-terminal nonkinase domain may contain a regulatory domain. Expression of MEKK4 in mammalian cells activated the CSBP2 and JNK MAPK pathways, but not the ERK pathway. In vitro kinase studies indicated that recombinant MEKK4 can specifically phosphorylate and activate PRKMK6 and SERK1, MAPKKs that activate CSBP2 and JNK, respectively but cannot phosphorylate PRKMK1, an MAPKK that activates ERKs. MEKK4 is a major mediator of environmental stresses that activate the CSBP2 MAPK pathway, and a minor mediator of the JNK pathway. Several alternatively spliced transcripts encoding distinct isoforms have been described.