Caspase-8 (p18) Recombinant Rabbit Monoclonal Antibody [PSH05-83] (HA722482)

UNIPROT #

O89110

PROTEIN NAME

Caspase-8 (p18)

SYNONYMS

ALPS2B antibody;Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein antibody;Apoptosis related cysteine peptidase antibody;Apoptotic cysteine protease antibody;Apoptotic protease Mch-5 antibody;Apoptotic protease Mch5 antibody;CAP 4 antibody;CAP4 antibody;CASP-8 antibody;CASP8 antibody;CASP8_HUMAN antibody;Caspase 8 antibody;Caspase 8 apoptosis related cysteine peptidase antibody;Caspase IIX antibody;Caspase-8 subunit p10 antibody;caspase8 antibody;CED 3 antibody;FADD Homologous ICE/CED3 Like Protease antibody;FADD Like ICE antibody;FADD-homologous ICE/CED-3-like protease antibody;FADD-like ICE antibody;FLICE antibody;FLJ17672 antibody;ICE-like apoptotic protease 5 antibody;MACH alpha 1/2/3 protein antibody;MACH antibody;MACH beta 1/2/3/4 protein antibody;MACH5 antibody;MCH 5 antibody;MCH5 antibody;MGC78473 antibody;MORT1 associated ced 3 homolog antibody;MORT1 associated CED3 homolog antibody;MORT1-associated CED-3 homolog antibody;OTTHUMP00000163717 antibody;OTTHUMP00000163720 antibody;OTTHUMP00000163724 antibody;OTTHUMP00000163725 antibody;OTTHUMP00000165062 antibody;OTTHUMP00000165063 antibody;OTTHUMP00000165064 antibody;OTTHUMP00000206552 antibody;OTTHUMP00000206582 antibody

SUBCELLULAR LOCATION

Cytoplasm. Nucleus.

FUNCTION

Thiol protease that plays a key role in programmed cell death by acting as a molecular switch for apoptosis, necroptosis and pyroptosis, and is required to prevent tissue damage during embryonic development and adulthood. Initiator protease that induces extrinsic apoptosis by mediating cleavage and activation of effector caspases responsible for FAS/CD95-mediated and TNFRSF1A-induced cell death. Cleaves and activates effector caspases CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10. Binding to the adapter molecule FADD recruits it to either receptor FAS/CD95 or TNFRSF1A. The resulting aggregate called the death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. In addition to extrinsic apoptosis, also acts as a negative regulator of necroptosis: acts by cleaving RIPK1 at 'Asp-325', which is crucial to inhibit RIPK1 kinase activity, limiting TNF-induced apoptosis, necroptosis and inflammatory response.