NAIP Recombinant Rabbit Monoclonal Antibody [JE39-24]

Function

Baculoviral IAP repeat-containing protein 1 is a protein that in humans is encoded by the NAIP gene. This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. This copy of the gene is full length; additional copies with truncations and internal deletions are also present in this region of chromosome 5q13. It is thought that this gene is a modifier of spinal muscular atrophy caused by mutations in a neighboring gene, SMN1. The protein encoded by this gene contains regions of homology to two baculovirus inhibitor of apoptosis proteins, and it is able to suppress apoptosis induced by various signals. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Background References

1. Egan MS et al. Human and mouse NAIP/NLRC4 inflammasome responses to bacterial infection. Curr Opin Microbiol. 2023 Jun

2. Bauer R et al. The NAIP/NLRC4 inflammasome in infection and pathology. Mol Aspects Med. 2020 Dec

Subcellular Location

Basolateral plasma membrane, canonical inflammasome complex, cytoplasm.

UNIPROT

SwissProt: Q13075 Human

Synonyms