Use at an assay dependent concentration. Can be paired for Sandwich ELISA with Rabbit monoclonal [PSH05-71] to Human LIF (Capture) (HA722423) and recombinant standard Human LIF protein (HA210736) as the standard. The reference range value is 8.2-2,000 pg/mL.
Target
Function
The protein encoded by this gene is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.
Background References
1. Chen Y., Gong Y., Qin H., Wei S., Wei Y., Yu Y., Lin X., Shuai P., Wang T., Yi L. MDM2-p53 mediate a miR-181c-3p/LIF axis to regulate low dose-rate radiation-induced DNA damage in human B lymphocytes. Ecotoxicol Environ Saf 270:115848-115848 (2024)
2. Hallett R.M., Bonfill-Teixidor E., Iurlaro R., Arias A., Raman S., Bayliss P., Egorova O., Neva-Alejo A., McGray A.R., Seoane J. Therapeutic Targeting of LIF Overcomes Macrophage-mediated Immunosuppression of the Local Tumor Microenvironment. Clin Cancer Res 29:791-804 (2023)
