Biotin Conjugated Mouse IL12 p40 Recombinant Rabbit Monoclonal Antibody [PSH04-88] (HA722603B)

UNIPROT #

P43432

PROTEIN NAME

Mouse IL12 p40

SYNONYMS

CLMF antibody;CLMF p40 antibody;CLMF2 antibody;Cytotoxic lymphocyte maturation factor 40 kDa subunit antibody;IL 12 subunit p40 antibody;IL 12B antibody;IL-12 subunit p40 antibody;IL-12B antibody;IL12 p40 antibody;IL12 subunit p40 antibody;IL12B antibody;IL12B_HUMAN antibody;interleukin 12 beta chain antibody;Interleukin 12 p40 antibody;Interleukin 12 subunit beta antibody;Interleukin 12B antibody;Interleukin-12 subunit beta antibody;natural killer cell stimulatory factor 40 kD subunit antibody;NK cell stimulatory factor chain 2 antibody;NKSF antibody;NKSF2 antibody;p40 antibody

SUBCELLULAR LOCATION

Secreted.

FUNCTION

Subunit beta of interleukin 12 (also known as IL-12B, natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor p40, or interleukin-12 subunit p40) is a protein subunit that in humans is encoded by the IL12B gene. IL-12B is a common subunit of interleukin 12 and interleukin 23. This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kDa cytokine receptor like subunit encoded by this gene, and a 35 kDa subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children.