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Biotin Conjugated Human MBL2 Recombinant Rabbit Monoclonal Antibody [PSH04-86]

Usd: 409

Specification

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Catalog# HA722604B

Biotin Conjugated Human MBL2 Recombinant Rabbit Monoclonal Antibody [PSH04-86]

Application

  • ELISA(Det)

Reactivity

  • Human

Pair: Capture
Pair: Detector
Pair: Protein
Range

  • 99-8,000 pg/mL

Conjugation

  • Biotin

Overview

Product Name

Biotin Conjugated Human MBL2 Recombinant Rabbit Monoclonal Antibody [PSH04-86]

Antibody Type

Recombinant Rabbit monoclonal Antibody

Immunogen

Recombinant protein within human MBL2 aa 108-248 (P11226).

Species Reactivity

Human

Validated Applications

ELISA(Det)

Molecular Weight

Predicted band size: 26 kDa

Positive Control

Recombinant Human MBL2 protein (HA210628).

Conjugation

Biotin

Clone Number

PSH04-86

Product Features

Form

Liquid

Concentration

1 mg/mL.(The concentration of this product may be batch-dependent)

Storage Instructions

Shipped at 4℃. Store at +4℃ short term (1-2 weeks). Store at -20℃ long term.

Storage Buffer

PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% ProClin300.

Isotype

IgG

Purification Method

Protein A affinity purified.

Application Dilution

  • ELISA(Det)

  • Use at an assay dependent concentration. Can be paired for Sandwich ELISA with Rabbit monoclonal [PSH04-85] to Human MBL2 (Capture) (HA722191) and recombinant standard Human MBL2 protein (HA210628). The reference range value is 99-8,000 pg/mL.

Target

Function

Mannose-binding lectin (MBL), also called mannan-binding lectin or mannan-binding protein (MBP), is a lectin that is instrumental in innate immunity as an opsonin and via the lectin pathway. MBL belongs to the class of collectins in the C-type lectin superfamily, whose function appears to be pattern recognition in the first line of defense in the pre-immune host. MBL recognizes carbohydrate patterns found on the surface of a large number of pathogenic micro-organisms, including bacteria, viruses, protozoa and fungi. Binding of MBL to a micro-organism results in activation of the lectin pathway of the complement system. Another important function of MBL is that this molecule binds senescent and apoptotic cells and enhances engulfment of whole, intact apoptotic cells, as well as cell debris by phagocytes.

Background References

1. Yuan ZC et al. Association of MBL2 gene polymorphisms and systemic lupus erythematosus susceptibility: A meta-analysis. Int J Rheum Dis. 2021 Feb

2. Sokkar MF et al. MBL2 gene variants and susceptibility to meningitis in Egyptian patients. Gene. 2023 Jul

Subcellular Location

Secreted.

UNIPROT

SwissProt: P11226 Human

Synonyms

COLEC 1 antibody

COLEC1 antibody

Collectin-1 antibody

HSMBPC antibody

Lectin, mannose-binding, soluble, 2 antibody

Mannan binding lectin antibody

Mannan binding protein antibody

Mannan-binding protein antibody

Mannose binding lectin (protein C) 2 soluble antibody

Mannose binding lectin (protein C) 2, soluble (opsonic defect) antibody

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"