Biotin Conjugated Human CRP Recombinant Rabbit Monoclonal Antibody [PSH04-26] - Detector

Function

C-reactive protein (CRP) is an annular (ring-shaped) pentameric protein found in blood plasma, whose circulating concentrations rise in response to inflammation. It is an acute-phase protein of hepatic origin that increases following interleukin-6 secretion by macrophages and T cells. Its physiological role is to bind to lysophosphatidylcholine expressed on the surface of dead or dying cells (and some types of bacteria) in order to activate the complement system via C1q. CRP is synthesized by the liver in response to factors released by macrophages and fat cells (adipocytes). It is a member of the pentraxin family of proteins. It is not related to C-peptide (insulin) or protein C (blood coagulation). C-reactive protein was the first pattern recognition receptor (PRR) to be identified.

Background References

1. Zhu M et al. C-reactive protein and cancer risk: a pan-cancer study of prospective cohort and Mendelian randomization analysis. BMC Med. 2022 Sep

2. Pathak A et al. Evolution of C-Reactive Protein. Front Immunol. 2019 Apr

Subcellular Location

Secreted.

UNIPROT

SwissProt: P02741 Human

Synonyms

Pentraxin 1, short antibody

C reactive protein antibody

C reactive protein pentraxin related antibody

C-reactive protein(1-205) antibody

CRP antibody

CRP_HUMAN antibody

MGC88244 antibody

Pentraxin 1 antibody

PTX 1 antibody

PTX1 antibody