Biotin Conjugated Human VE Cadherin Recombinant Rabbit Monoclonal Antibody [PSH02-62] - Detector

Function

VE-cadherin is a member of the cadherin superfamily that is located in a six-cadherin cluster in a region on the long arm of chromosome 16 and is involved in loss of heterozygosity events in breast and prostate cancer. VE-cadherin protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classic cadherin by imparting to cells the ability to adhere in a homophilic manner, VE-cadherin may play an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. An alternative splice variant has been described but the full length sequence of VE-cadherin has not been determined.

Background References

1. Shimoyama Y., Tsujimoto G., Kitajima M., Natori M. Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins. Biochem. J. 349:159-167 (2000)

2. Lampugnani M.G., Orsenigo F., Rudini N., Maddaluno L., Boulday G., Chapon F., Dejana E. CCM1 regulates vascular-lumen organization by inducing endothelial polarity. J. Cell Sci. 123:1073-1080 (2010)

3. Brasch J., Harrison O.J., Ahlsen G., Carnally S.M., Henderson R.M., Honig B., Shapiro L. Structure and binding mechanism of vascular endothelial cadherin: a divergent classical cadherin. J. Mol. Biol. 408:57-73 (2011)

Subcellular Location

Cell junction. Cell membrane. Membrane.

UNIPROT

SwissProt: P33151 Human

Synonyms