Use at an assay dependent concentration. Can be paired for Sandwich ELISA with Rabbit monoclonal [PSH02-72] to Mouse VEGF (Capture) (HA721850). The reference range value is 13.72-10,000 pg/mL.
Target
Function
Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. Binds to the NRP1/neuropilin-1 receptor. Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development. In developing embryos, expressed mainly in the choroid plexus, paraventricular neuroepithelium, placenta and kidney glomeruli. Also found in bronchial epithelium, adrenal gland and in seminiferous tubules of testis. High expression continues in kidney glomeruli and choroid plexus in adults.
Background References
1. He W., Bai G., Zhou H., Wei N., White N.M., Lauer J., Liu H., Shi Y., Dumitru C.D., Lettieri K., Shubayev V., Jordanova A., Guergueltcheva V., Griffin P.R., Burgess R.W., Pfaff S.L., Yang X.L. CMT2D neuropathy is linked to the neomorphic binding activity of glycyl- tRNA synthetase. Nature 526:710-714 (2015)
2. Katsman M., Azriel A., Horev G., Reizel Y., Levi B.Z. N-VEGF, the Autoregulatory Arm of VEGF-A. Cells 11:0-0 (2022)
