Biotin Conjugated Mouse VEGF Recombinant Rabbit Monoclonal Antibody [PSH02-73] (HA722636B)

UNIPROT #

Q00731

PROTEIN NAME

Mouse VEGF

SYNONYMS

Folliculostellate cell-derived growth factor antibody;Glioma-derived endothelial cell mitogen antibody;MGC70609 antibody;MVCD1 antibody;Vascular endothelial growth factor A antibody;vascular endothelial growth factor A121 antibody;vascular endothelial growth factor A165 antibody;vascular endothelial growth factor antibody;Vascular permeability factor antibody;VEGF A antibody;Vegf antibody;VEGF-A antibody;VEGF120 antibody;Vegfa antibody;VEGFA_HUMAN antibody;VPF antibody

SUBCELLULAR LOCATION

Secreted.

FUNCTION

Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. Binds to the NRP1/neuropilin-1 receptor. Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development. In developing embryos, expressed mainly in the choroid plexus, paraventricular neuroepithelium, placenta and kidney glomeruli. Also found in bronchial epithelium, adrenal gland and in seminiferous tubules of testis. High expression continues in kidney glomeruli and choroid plexus in adults.