Biotin Conjugated Rat IL-10 Recombinant Rabbit Monoclonal Antibody [PSH02-22] (HA722637B)

UNIPROT #

P29456

PROTEIN NAME

Rat IL-10

SYNONYMS

CSIF antibody;Cytokine synthesis inhibitory factor antibody;GVHDS antibody;IL 10 antibody;IL-10 antibody;IL10 antibody;IL10_HUMAN antibody;IL10A antibody;Interleukin 10 antibody;Interleukin-10 antibody;MGC126450 antibody;MGC126451 antibody;T-cell growth inhibitory factor antibody;TGIF antibody

SUBCELLULAR LOCATION

Secreted

FUNCTION

Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF-alpha. Interferes also with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation.