TEAD2 Recombinant Rabbit Monoclonal Antibody [PSH07-32]
Catalog# HA722820
TEAD2 Recombinant Rabbit Monoclonal Antibody [PSH07-32]
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WB
-
Human
-
Mouse
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HA751153
不含抗保成分
-
unconjugated
Overview
Product Name
TEAD2 Recombinant Rabbit Monoclonal Antibody [PSH07-32]
Antibody Type
Recombinant Rabbit monoclonal Antibody
Immunogen
Recombinant protein within human TEAD2 aa 101-300.
Species Reactivity
Human, Mouse
Validated Applications
WB
Molecular Weight
Predicted band size: 49 kDa
Positive Control
Huh7 cell lysate, MDA-MB-231 cell lysate, A549 cell lysate, HeLa cell lysate, NIH/3T3 cell lysate.
Conjugation
unconjugated
Clone Number
PSH07-32
Reactivity Data
| WB | |
|---|---|
| Human |
|
| Mouse |
|
| Rat |
Product Features
Form
Liquid
Concentration
Storage Instructions
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). Store at -20℃ long term.
Storage Buffer
PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Isotype
IgG
Purification Method
Protein A affinity purified.
Application Dilution
-
WB
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1:2,000
Target
Function
TEAD2 (ETF, ETEF-1, TEF-4), together with TEAD1, defines a novel family of transcription factors, the TEAD family, highly conserved through evolution. TEAD proteins were notably found in Drosophila (Scalloped), C. elegans (egl -44), S. cerevisiae and A. nidulans. TEAD2 has been less studied than TEAD1 but a few studies revealed its role during development. TEAD2 is a member of the mammalian TEAD transcription factor family (initially named the transcriptional enhancer factor (TEF) family), which contain the TEA/ATTS DNA-binding domain. Members of the family in mammals are TEAD1, TEAD2, TEAD3, TEAD4.
Background References
1. Saito Y et al. A Therapeutically Targetable TAZ-TEAD2 Pathway Drives the Growth of Hepatocellular Carcinoma via ANLN and KIF23. Gastroenterology. 2023 Jun
2. Park S et al. Transcription factors TEAD2 and E2A globally repress acetyl-CoA synthesis to promote tumorigenesis. Mol Cell. 2022 Nov
Subcellular Location
Nucleus.
Synonyms
Embryonic TEA domain containing factor antibody
Etdf antibody
ETEF 1 antibody
ETF antibody
TEA domain family member 2 antibody
TEAD 2 antibody
TEAD-2 antibody
TEAD2 antibody
Tead2 protein (TEA domain family member 2 (Mapped), isoform CRA_b) antibody
TEAD2_HUMAN antibody
ExpandImages
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Western blot analysis of TEAD2 on different lysates with Rabbit anti-TEAD2 antibody (HA722820) at 1/2,000 dilution.
Lane 1: Huh7 cell lysate
Lane 2: MDA-MB-231 cell lysate
Lane 3: A549 cell lysate
Lane 4: HeLa cell lysate
Lane 5: NIH/3T3 cell lysate
Lysates/proteins at 20 µg/Lane.
Predicted band size: 49 kDa
Observed band size: 55 kDa
Exposure time: 3 minutes; ECL: K1801;
4-20% SDS-PAGE gel.
Proteins were transferred to a PVDF membrane and blocked with 5% NFDM/TBST for 1 hour at room temperature. The primary antibody (HA722820) at 1/2,000 dilution was used in 5% NFDM/TBST at 4℃ overnight. Goat Anti-Rabbit IgG - HRP Secondary Antibody (HA1001) at 1/50,000 dilution was used for 1 hour at room temperature.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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