TRAF6 Recombinant Rabbit Monoclonal Antibody [JE01-42] (HA722857)

UNIPROT #

Q9Y4K3

PROTEIN NAME

TRAF6

SYNONYMS

E3 ubiquitin-protein ligase TRAF6 antibody;Interleukin 1 signal transducer antibody;Interleukin-1 signal transducer antibody;MGC 3310 antibody;MGC:3310 antibody;MGC3310 antibody;OTTHUMP00000232772 antibody;OTTHUMP00000232773 antibody;RING finger protein 85 antibody;RNF 85 antibody;RNF85 antibody;TNF receptor associated factor 6 antibody;TNF receptor-associated factor 6 antibody;TNF receptor-associated factor 6, E3 ubiquitin protein ligase antibody;TRAF 6 antibody;Traf6 antibody;TRAF6_HUMAN antibody

SUBCELLULAR LOCATION

Cytoplasm, cell cortex, Nucleus, Lipid droplet.

FUNCTION

The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. This protein mediates the signaling not only from the members of the TNF receptor superfamily, but also from the members of the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/TRANCE/RANKL and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. Two alternatively spliced transcript variants encoding identical proteins have been reported.