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Placental lactogen Recombinant Rabbit Monoclonal Antibody [JE60-49]

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Specification

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Catalog# HA722865

Placental lactogen Recombinant Rabbit Monoclonal Antibody [JE60-49]

Application

  • IHC-P

Reactivity

  • Human

Conjugation

  • unconjugated

Overview

Product Name

Placental lactogen Recombinant Rabbit Monoclonal Antibody [JE60-49]

Antibody Type

Recombinant Rabbit monoclonal Antibody

Immunogen

Synthetic peptide within human Placental lactogen aa 101-150 / 217.

Species Reactivity

Human

Validated Applications

IHC-P

Molecular Weight

Predicted band size: 25 kDa

Positive Control

Human placenta tissue.

Conjugation

unconjugated

Clone Number

JE60-49

Reactivity Data

IHC-P
Human
Tested Tested
Mouse
Not Recommended
Rat
Not Recommended

Product Features

Form

Liquid

Concentration

1 mg/mL.(The concentration of this product may be batch-dependent)

Storage Instructions

Shipped at 4℃. Store at +4℃ short term (1-2 weeks). Store at -20℃ long term.

Storage Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Isotype

IgG

Purification Method

Protein A affinity purified.

Application Dilution

  • IHC-P

  • 1:1,000

Target

Function

Placental lactogen, also called chorionic somatomammotropin, is a polypeptide placental hormone, part of the somatotropin family. Its structure and function is similar to that of growth hormone. It modifies the metabolic state of the mother during pregnancy to facilitate the energy supply of the fetus. Placental lactogen I and II were identified as prolactin-like molecules that can bind to prolactin receptor with high affinity and mimic the actions of prolactin. These hormones can contribute to lactogenesis, luteal maintenance and progesterone production (in rats) during the later stages of gestation. Placental lactogen I may be important in stimulating mammary cell proliferation and in stimulating some of the adaptations of the maternal lipid and carbohydrate metabolism.

Background References

1. Cattini PA, Jin Y, Jarmasz JS, Noorjahan N, Bock ME. Obesity and regulation of human placental lactogen production in pregnancy. J Neuroendocrinol. 2020 Nov;32(11):e12859. doi: 10.1111/jne.12859. Epub 2020 Jun 5. PMID: 32500948.

2. Walker WH, Fitzpatrick SL, Barrera-Saldaña HA, Resendez-Perez D, Saunders GF. The human placental lactogen genes: structure, function, evolution and transcriptional regulation. Endocr Rev. 1991 Nov;12(4):316-28. doi: 10.1210/edrv-12-4-316. PMID: 1760991.

Subcellular Location

Secreted.

UNIPROT

SwissProt: P0DML2 Human

SwissProt: P0DML3 Human

Synonyms

Choriomammotropin antibody

Chorionic somatomammotropin A antibody

chorionic somatomammotropin B antibody

chorionic somatomammotropin hormone 1 (placental lactogen) antibody

Chorionic somatomammotropin hormone 1 antibody

chorionic somatomammotropin hormone 2 antibody

Chorionic somatomammotropin hormone antibody

CS 2 antibody

CS-2 antibody

CS1 antibody

Expand

Images

  • Immunohistochemical analysis of paraffin-embedded human placenta tissue with Rabbit anti-Placental lactogen antibody (<a href="/products/HA722865" style="font-weight: bold;text-decoration: underline;">HA722865</a>) at 1/1,000 dilution.<br /><br />The section was pre-treated using heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 20 minutes. The tissues were blocked in 1% BSA for 20 minutes at room temperature, washed with ddH<sub>2</sub>O and PBS, and then probed with the primary antibody (<a href="/products/HA722865" style="font-weight: bold;text-decoration: underline;">HA722865</a>) at 1/1,000 dilution for 1 hour at room temperature. The detection was performed using an HRP conjugated compact polymer system. DAB was used as the chromogen. Tissues were counterstained with hematoxylin and mounted with DPX.

    Immunohistochemical analysis of paraffin-embedded human placenta tissue with Rabbit anti-Placental lactogen antibody (HA722865) at 1/1,000 dilution.

    The section was pre-treated using heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 20 minutes. The tissues were blocked in 1% BSA for 20 minutes at room temperature, washed with ddH2O and PBS, and then probed with the primary antibody (HA722865) at 1/1,000 dilution for 1 hour at room temperature. The detection was performed using an HRP conjugated compact polymer system. DAB was used as the chromogen. Tissues were counterstained with hematoxylin and mounted with DPX.

  • <span style="font-weight: bold;">☑ Relative expression (RE)</span><br /><br />Immunohistochemical analysis of paraffin-embedded human kidney tissue (negative) with Rabbit anti-Placental lactogen antibody (<a href="/products/HA722865" style="font-weight: bold;text-decoration: underline;">HA722865</a>) at 1/1,000 dilution.<br /><br />The section was pre-treated using heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 20 minutes. The tissues were blocked in 1% BSA for 20 minutes at room temperature, washed with ddH<sub>2</sub>O and PBS, and then probed with the primary antibody (<a href="/products/HA722865" style="font-weight: bold;text-decoration: underline;">HA722865</a>) at 1/1,000 dilution for 1 hour at room temperature. The detection was performed using an HRP conjugated compact polymer system. DAB was used as the chromogen. Tissues were counterstained with hematoxylin and mounted with DPX.

    ☑ Relative expression (RE)

    Immunohistochemical analysis of paraffin-embedded human kidney tissue (negative) with Rabbit anti-Placental lactogen antibody (HA722865) at 1/1,000 dilution.

    The section was pre-treated using heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 20 minutes. The tissues were blocked in 1% BSA for 20 minutes at room temperature, washed with ddH2O and PBS, and then probed with the primary antibody (HA722865) at 1/1,000 dilution for 1 hour at room temperature. The detection was performed using an HRP conjugated compact polymer system. DAB was used as the chromogen. Tissues were counterstained with hematoxylin and mounted with DPX.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"