METTL14 Recombinant Rabbit Monoclonal Antibody [PSH07-85] (HA722910)

UNIPROT #

Q9HCE5

PROTEIN NAME

METTL14

SYNONYMS

KIAA1627 antibody;MET14_HUMAN antibody;Methyltransferase like 14 antibody;Methyltransferase-like protein 14 antibody;METTL14 antibody;N6-adenosine-methyltransferase subunit METTL14 antibody;OTTHUMP00000219837 antibody

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis. In the heterodimer formed with METTL3, METTL14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core. N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and processing. M6A acts as a key regulator of mRNA stability by promoting mRNA destabilization and degradation (By similarity). In embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization (By similarity). M6A regulates spermatogonial differentiation and meiosis and is essential for male fertility and spermatogenesis (By similarity). M6A also regulates cortical neurogenesis: m6A methylation of transcripts related to transcription factors, neural stem cells, the cell cycle and neuronal differentiation during brain development promotes their destabilization and decay, promoting differentiation of radial glial cells (By similarity).