NK1.1 Recombinant Rabbit Monoclonal Antibody [PSH08-46]
Catalog# HA722992
NK1.1 Recombinant Rabbit Monoclonal Antibody [PSH08-46]
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FC
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Mouse
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HA751221
不含抗保成分
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unconjugated
Overview
Product Name
NK1.1 Recombinant Rabbit Monoclonal Antibody [PSH08-46]
Antibody Type
Recombinant Rabbit monoclonal Antibody
Immunogen
Recombinant protein within mouse NK1.1 aa 67-223.
Species Reactivity
Mouse
Validated Applications
FC
Molecular Weight
Predicted band size: 25 kDa
Positive Control
C57BL/6 mouse spleen cells.
Conjugation
unconjugated
Clone Number
PSH08-46
Reactivity Data
| FC | |
|---|---|
| Mouse |
|
Product Features
Form
Liquid
Concentration
Storage Instructions
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). Store at -20℃ long term.
Storage Buffer
PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Isotype
IgG
Purification Method
Protein A affinity purified.
Application Dilution
-
FC
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1:400
Target
Function
Killer cell lectin-like receptor subfamily B, member 1, also known as KLRB1, NKR-P1A or CD161 (cluster of differentiation 161), is a human gene. Natural killer (NK) cells are lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation. Several genes of the C-type lectin superfamily, including the rodent NKRP1 family of glycoproteins, are expressed by NK cells and may be involved in the regulation of NK cell function. The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins, a transmembrane domain, and a cytoplasmic domain. The KLRB1 protein, NKR-P1A or CD161, is classified as a type II membrane protein because it has an external C terminus. NKR-P1A, the receptor encoded by the KLRB1 gene, recognizes Lectin Like Transcript-1 (LLT1) as a functional ligand. Its engagement by NKR-P1 leads to clustering of the latter on the NK cell surface mediating an inhibitory signalling.
Background References
1. Tian D et al. TCRalphabeta(+)NK1.1(-)CD4(-)CD8(-) double-negative T cells inhibit central and peripheral inflammation and ameliorate ischemic stroke in mice. Theranostics. 2023 Jan
2. An JN et al. NK1.1(-) natural killer T cells upregulate interleukin-17 expression in experimental lupus nephritis. Am J Physiol Renal Physiol. 2021 May
Subcellular Location
Membrane.
UNIPROT
Synonyms
CD161 antigen like family member C antibody
CD161 antigen-like family member C antibody
CD161c antibody
Killer cell lectin-like receptor subfamily B member 1C antibody
Klrb1c antibody
Klrb1f antibody
KLRBC_MOUSE antibody
Ly-55c antibody
Ly55c antibody
Lymphocyte antigen 55c antibody
ExpandImages
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Flow cytometric analysis of C57BL/6 mouse spleen cells labeling NK1.1.
Cells were washed twice with cold PBS and resuspend. Then stained with the primary antibody (HA722992, 1/400). After incubation of the primary antibody at +4℃ for an hour, the cells were stained with a iFluor™ 594 conjugate-Goat anti-Rabbit IgG Secondary antibody (HA1122) at 1/1,000 dilution for 30 minutes at +4℃.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"