eIF3g Recombinant Rabbit Monoclonal Antibody [PSH09-42]

Function

RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.

Background References

1. Chang J et al. An interaction between eIF4A3 and eIF3g drives the internal initiation of translation. Nucleic Acids Res. 2023 Nov

2. Zhang X et al. Long non-coding RNA LINC02446 suppresses the proliferation and metastasis of bladder cancer cells by binding with EIF3G and regulating the mTOR signalling pathway. Cancer Gene Ther. 2021 Dec

Subcellular Location

Cytoplasm, Nucleus, perinuclear region.

UNIPROT

SwissProt: O75821 Human

SwissProt: Q9Z1D1 Mouse

SwissProt: Q5RK09 Rat

Synonyms