CD81 Recombinant Rabbit Monoclonal Antibody [PSH10-26] (HA723193)

UNIPROT #

P60033

PROTEIN NAME

CD81

SYNONYMS

26 kDa cell surface protein TAPA 1 antibody;26 kDa cell surface protein TAPA-1 antibody;26 kDa cell surface protein TAPA1 antibody;CD 81 antibody;CD81 antibody;CD81 antigen (target of antiproliferative antibody 1) antibody;CD81 antigen antibody;CD81 molecule antibody;CD81_HUMAN antibody;CVID6 antibody;S5.7 antibody;TAPA 1 antibody;TAPA1 antibody;Target of the antiproliferative antibody 1 antibody;Tetraspanin 28 antibody;Tetraspanin-28 antibody;Tetraspanin28 antibody;Tspan 28 antibody;Tspan-28 antibody;Tspan28 antibody

SUBCELLULAR LOCATION

Cell membrane, Basolateral cell membrane.

FUNCTION

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This protein appears to promote muscle cell fusion and support myotube maintenance. Also it may be involved in signal transduction. This gene is localized in the tumor-suppressor gene region and thus it is a candidate gene for malignancies. The tetraspanin family includes CD9, CD37, CD53, CD63, CD81 (this protein), CD82 and CD151. CD81 interacts directly with immunoglobulin superfamily member 8 (IGSF8, CD316) and CD36. It forms a signal transduction complex with CD19, CD21 and Leu-13 (CD225) on the surface of the B cell. On T cells CD81 associates with CD4 and CD8 and provides a costimulatory signal with CD3.