DAG1 Recombinant Rabbit Monoclonal Antibody [PSH13-91]

Function

Dystroglycan (DG) is a cell surface receptor for several extracellular matrix molecules including laminins, Agrin and Perlecan. Dystroglycan function is required for the formation of basement membranes in early development and the organization of Laminin on the cell surface. α-dystroglycan is a membrane- associated, extracellular glycoprotein that is anchored to the cell-membrane by binding to the transmembrane glycoprotein α-dystroglycan to form an α/β-dystroglycan-complex. Additionally, dystroglycan is part of a multimolecular complex, where it associates with dystrophin, at the sarcolemma, to form the dystrophin-associated protein complex, or with utrophin, at the neuromuscular junction, to form the utrophin-associated protein complex. Dystroglycan is also thought to participate in the clustering of nicotinic acetylcholine receptors at the neuromuscular junction.

Background References

1. Traverso M et al. DAG1 haploinsufficiency is associated with sporadic and familial isolated or pauci-symptomatic hyperCKemia. Eur J Hum Genet. 2024 Mar

2. Yao J et al. Fat Mass- and Obesity-Associated Protein (FTO) Promotes the Proliferation of Goat Skeletal Muscle Satellite Cells by Stabilizing DAG1 mRNA in an IGF2BP1-Related m(6)A Manner. Int J Mol Sci. 2024 Sep

Subcellular Location

Secreted, extracellular space; Cell membrane, Cytoplasm, cytoskeleton, Nucleus, nucleoplasm, sarcolemma, Postsynaptic cell membrane.

UNIPROT

SwissProt: Q14118 Human

SwissProt: Q62165 Mouse

Entrez Gene: 114489 Rat

Synonyms