C Reactive Protein Recombinant Rabbit Multiclonal Antibody [PSH15-35]
Catalog# HA723739
C Reactive Protein Recombinant Rabbit Multiclonal Antibody [PSH15-35]
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WB
-
Human
-
Mouse
-
Rat
-
unconjugated
Overview
Product Name
C Reactive Protein Recombinant Rabbit Multiclonal Antibody [PSH15-35]
Antibody Type
Recombinant Rabbit multiclonal
Species Reactivity
Human, Mouse, Rat
Validated Applications
WB
Molecular Weight
Predicted band size: 25 kDa
Positive Control
Human serum tissue lysate, Human plasma tissue lysate, Mouse serum tissue lysate, Mouse plasma tissue lysate, Rat plasma tissue lysate.
Conjugation
unconjugated
Clone Number
PSH15-35
Reactivity Data
| WB | |
|---|---|
| Human |
|
| Mouse |
|
| Rat |
|
Product Features
Form
Liquid
Concentration
Storage Instructions
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20℃ long term.
Storage Buffer
PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Isotype
IgG
Purification Method
Protein A affinity purified.
Application Dilution
-
WB
-
1:5,000
Target
Function
C-reactive protein (CRP) is an annular (ring-shaped) pentameric protein found in blood plasma, whose circulating concentrations rise in response to inflammation. It is an acute-phase protein of hepatic origin that increases following interleukin-6 secretion by macrophages and T cells. Its physiological role is to bind to lysophosphatidylcholine expressed on the surface of dead or dying cells (and some types of bacteria) in order to activate the complement system via C1q. CRP is synthesized by the liver in response to factors released by macrophages, T cells and fat cells (adipocytes). It is a member of the pentraxin family of proteins. It is not related to C-peptide (insulin) or protein C (blood coagulation). C-reactive protein was the first pattern recognition receptor (PRR) to be identified.
Background References
1. Zhu M et al. C-reactive protein and cancer risk: a pan-cancer study of prospective cohort and Mendelian randomization analysis. BMC Med. 2022 Sep
2. Pope JE et al. C-reactive protein and implications in rheumatoid arthritis and associated comorbidities. Semin Arthritis Rheum. 2021 Feb
Subcellular Location
Secreted.
Synonyms
Pentraxin 1, short antibody
C reactive protein antibody
C reactive protein pentraxin related antibody
C-reactive protein(1-205) antibody
CRP antibody
CRP_HUMAN antibody
MGC88244 antibody
Pentraxin 1 antibody
PTX 1 antibody
PTX1 antibody
Images
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Western blot analysis of C Reactive Protein on different lysates with Rabbit anti-C Reactive Protein antibody (HA723739) at 1/5,000 dilution.
Lane 1: Human serum tissue lysate
Lane 2: Human plasma tissue lysate
Lysates/proteins at 40 µg/Lane.
Predicted band size: 25 kDa
Observed band size: 25 kDa
Exposure time: 7 seconds; ECL: K1801;
4-20% SDS-PAGE gel.
Proteins were transferred to a PVDF membrane and blocked with 5% NFDM/TBST for 1 hour at room temperature. The primary antibody (HA723739) at 1/5,000 dilution was used in primary antibody dilution (K1803) at 4℃ overnight. Goat Anti-Rabbit IgG - HRP Secondary Antibody (HA1001) at 1/50,000 dilution was used for 1 hour at room temperature. -
Western blot analysis of C Reactive Protein on different lysates with Rabbit anti-C Reactive Protein antibody (HA723739) at 1/5,000 dilution.
Lane 1: Mouse serum tissue lysate
Lane 2: Mouse plasma tissue lysate
Lane 3: Rat plasma tissue lysate
Lysates/proteins at 40 µg/Lane.
Predicted band size: 25 kDa
Observed band size: 25 kDa
Exposure time: 7 seconds; ECL: K1801;
4-20% SDS-PAGE gel.
Proteins were transferred to a PVDF membrane and blocked with 5% NFDM/TBST for 1 hour at room temperature. The primary antibody (HA723739) at 1/5,000 dilution was used in primary antibody dilution (K1803) at 4℃ overnight. Goat Anti-Rabbit IgG - HRP Secondary Antibody (HA1001) at 1/50,000 dilution was used for 1 hour at room temperature.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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