SIRT4 Recombinant Rabbit Monoclonal Antibody [PSH15-46] (HA723752)

UNIPROT #

Q9Y6E7

PROTEIN NAME

SIRT4

SYNONYMS

MGC130046 antibody;MGC130047 antibody;MGC57437 antibody;NAD dependent deacetylase sirtuin 4 antibody;NAD dependent protein deacetylase sirtuin 4 antibody;NAD-dependent ADP-ribosyltransferase sirtuin-4 antibody;NAD-dependent protein deacetylase sirtuin-4 antibody;NAD-dependent protein lipoamidase sirtuin-4, mitochondrial antibody;Regulatory protein SIR2 homolog 4 antibody;Silent mating type information regulation 2 homolog antibody;Sir 2 like 4 antibody;SIR 2 like protein 4 antibody;Sir2 like 4 antibody;SIR2 like protein 4 antibody;SIR2-like protein 4 antibody;SIR2L 4 antibody;SIR2L4 antibody;SIR4_HUMAN antibody;SIRT 4 antibody;Sirt4 antibody;Sirtuin (silent mating type information regulation 2 homolog) 4 antibody;Sirtuin (silent mating type information regulation 2 homolog) 4 (S. cerevisiae) antibody;Sirtuin 4 antibody;Sirtuin type 4 antibody;Sirtuin-4 antibody;Sirtuin4 antibody

SUBCELLULAR LOCATION

Mitochondrion matrix.

FUNCTION

Sirtuin 4, also known as SIRT4, is a mitochondrial protein which in humans is encoded by the SIRT4 gene. SIRT4 is member of the mammalian sirtuin family of proteins, which are homologs to the yeast Sir2 protein. SIRT4 exhibits NAD+-dependent deacetylase activity. SIRT4 is a mitochondrial ADP-ribosyltransferase that inhibits mitochondrial glutamate dehydrogenase 1 activity, thereby downregulating insulin secretion in response to amino acids. A deacetylation of malonyl-CoA decarboxylase enzyme by SIRT4 represses the enzyme activity, inhibiting fatty acid oxidation in muscle and liver cells. SIRT4 has a suppressive effect on peroxisome proliferator-activated receptor alpha (PPAR-α) which downregulates fatty acid oxidation in liver cells. Deacetylation of ADP/ATP translocase 2 (ANT2) increases cellular ATP by dampening mitochondrial uncoupling.