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BCMA Recombinant Rabbit Monoclonal Antibody [PSH16-80]

Usd: 119

Specification

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Catalog# HA723880

BCMA Recombinant Rabbit Monoclonal Antibody [PSH16-80]

Application

  • FC

Reactivity

  • Human

BSA and Azide free
Conjugation

  • unconjugated

Overview

Product Name

BCMA Recombinant Rabbit Monoclonal Antibody [PSH16-80]

Antibody Type

Recombinant Rabbit monoclonal Antibody

Species Reactivity

Human

Validated Applications

FC

Molecular Weight

Predicted band size: 20 kDa

Positive Control

U266.

Conjugation

unconjugated

Clone Number

PSH16-80

Reactivity Data

FC
Human
Tested Tested

Product Features

Form

Liquid

Concentration

1mg/ml

Storage Instructions

Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*PBS (pH7.4).

Isotype

IgG

Purification Method

Protein A affinity purified.

Application Dilution

  • FC

  • 1:1000

Target

Function

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation.Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK.

Background References

1. Laâbi Y, Gras MP, Carbonnel F, Brouet JC, Berger R, Larsen CJ, Tsapis A. A new gene, BCM, on chromosome 16 is fused to the interleukin 2 gene by a t(4;16)(q26;p13) translocation in a malignant T cell lymphoma. EMBO J. 1992 Nov;11(11):3897-904. doi: 10.1002/j.1460-2075.1992.tb05482.x. PMID: 1396583; PMCID: PMC556899.

2. Laabi Y, Gras MP, Brouet JC, Berger R, Larsen CJ, Tsapis A. The BCMA gene, preferentially expressed during B lymphoid maturation, is bidirectionally transcribed. Nucleic Acids Res. 1994 Apr 11;22(7):1147-54. doi: 10.1093/nar/22.7.1147. PMID: 8165126; PMCID: PMC523635.

Subcellular Location

Cell membrane, Endomembrane system.

UNIPROT

SwissProt: Q02223 human

Synonyms

B cell maturation antigen antibody

B cell maturation factor antibody

B cell maturation protein antibody

B-cell maturation protein antibody

BCM antibody

BCMA antibody

CD269 antibody

CD269 antigen antibody

TNFRSF17 antibody

TNR17_HUMAN antibody

Expand

Images

  • Flow cytometric analysis of U266 cells labeling BCMA.<br /><br />Cells were washed twice with cold PBS and resuspend. Then stained with the primary antibody (<a href="/products/HA723880" style="font-weight: bold;text-decoration: underline;">HA723880</a>, 1/1,000) (red) compared with Rabbit IgG Isotype Control (green). After incubation of the primary antibody at +4℃ for an hour, the cells were stained with a FITC Conjugated Goat anti-rabbit IgG polyclonal Antibody (HA1124) at 1/1,000 dilution for 30 minutes at +4℃. Unlabelled sample was used as a control (cells without incubation with primary antibody; black).

    Flow cytometric analysis of U266 cells labeling BCMA.

    Cells were washed twice with cold PBS and resuspend. Then stained with the primary antibody (HA723880, 1/1,000) (red) compared with Rabbit IgG Isotype Control (green). After incubation of the primary antibody at +4℃ for an hour, the cells were stained with a FITC Conjugated Goat anti-rabbit IgG polyclonal Antibody (HA1124) at 1/1,000 dilution for 30 minutes at +4℃. Unlabelled sample was used as a control (cells without incubation with primary antibody; black).

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"