BCMA Recombinant Rabbit Monoclonal Antibody [PSH16-80]
Catalog# HA723880
BCMA Recombinant Rabbit Monoclonal Antibody [PSH16-80]
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FC
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Human
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unconjugated
Overview
Product Name
BCMA Recombinant Rabbit Monoclonal Antibody [PSH16-80]
Antibody Type
Recombinant Rabbit monoclonal Antibody
Species Reactivity
Human
Validated Applications
FC
Target Molecular Weight
Predicted band size: 20 kDa
Positive Control
U266.
Conjugation
unconjugated
Clone Number
PSH16-80
Reactivity Data
| FC | |
|---|---|
| Human |
|
Product Features
Form
Liquid
Concentration
1mg/ml
Storage Instructions
Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
Storage Buffer
1*PBS (pH7.4).
Isotype
IgG
Purification Method
Protein A affinity purified.
Application Dilution
-
FC
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1:1000
Target
Function
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation.Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK.
Background References
1. Laâbi Y, Gras MP, Carbonnel F, Brouet JC, Berger R, Larsen CJ, Tsapis A. A new gene, BCM, on chromosome 16 is fused to the interleukin 2 gene by a t(4;16)(q26;p13) translocation in a malignant T cell lymphoma. EMBO J. 1992 Nov;11(11):3897-904. doi: 10.1002/j.1460-2075.1992.tb05482.x. PMID: 1396583; PMCID: PMC556899.
2. Laabi Y, Gras MP, Brouet JC, Berger R, Larsen CJ, Tsapis A. The BCMA gene, preferentially expressed during B lymphoid maturation, is bidirectionally transcribed. Nucleic Acids Res. 1994 Apr 11;22(7):1147-54. doi: 10.1093/nar/22.7.1147. PMID: 8165126; PMCID: PMC523635.
Subcellular Location
Cell membrane, Endomembrane system.
UNIPROT
Synonyms
B cell maturation antigen antibody
B cell maturation factor antibody
B cell maturation protein antibody
B-cell maturation protein antibody
BCM antibody
BCMA antibody
CD269 antibody
CD269 antigen antibody
TNFRSF17 antibody
TNR17_HUMAN antibody
ExpandImages
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Flow cytometric analysis of U266 cells labeling BCMA.
Cells were washed twice with cold PBS and resuspend. Then stained with the primary antibody (HA723880, 1/1,000) (red) compared with Rabbit IgG Isotype Control (green). After incubation of the primary antibody at +4℃ for an hour, the cells were stained with a FITC Conjugated Goat anti-rabbit IgG polyclonal Antibody (HA1124) at 1/1,000 dilution for 30 minutes at +4℃. Unlabelled sample was used as a control (cells without incubation with primary antibody; black).
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"