Phospho-Axl (Y702) Recombinant Rabbit Monoclonal Antibody [PSH17-98]

Function

Tyrosine-protein kinase receptor UFO is a protein that in human is encoded by the AXL gene. The gene was initially designated as UFO, in allusion to the unidentified function of this protein. However, in the years since its discovery, research into AXL's expression profile and mechanism has made it an increasingly attractive target, especially for cancer therapeutics. In recent years, AXL has emerged as a key facilitator of immune escape and drug-resistance by cancer cells, leading to aggressive and metastatic cancers. AXL is a cell surface receptor tyrosine kinase, part of the TAM family of kinases including TYRO3 and MERTK.

Background References

1. Tanaka M et al. Therapeutic Targeting of the Gas6/Axl Signaling Pathway in Cancer. Int J Mol Sci. 2021 Sep

2. Adam-Artigues A et al. AXL - a new player in resistance to HER2 blockade. Cancer Treat Rev. 2023 Dec

Subcellular Location

Cell membrane.

UNIPROT

SwissProt: P30530 Human

Synonyms