MEK1/2 Recombinant Rabbit Monoclonal Antibody - BSA and Azide free [SR13-07] (HA750042)

UNIPROT #

P36507

PROTEIN NAME

MEK1/2

SYNONYMS

AA589381 antibody;CFC3 antibody;Dual specificity mitogen-activated protein kinase kinase 1 antibody;Dual specificity mitogen-activated protein kinase kinase 2 antibody;EC 2.7.12.2 antibody;ERK activator kinase 1 antibody;ERK activator kinase 2 antibody;FLJ26075 antibody;MAP kinase kinase 1 antibody;MAP kinase kinase 2 antibody;MAP2K1 antibody;MAP2K2 antibody;MAPK/ERK kinase 1 antibody;MAPK/ERK kinase 2 antibody;MAPKK 1 antibody;MAPKK1 antibody;MAPKK2 antibody;MEK 1 antibody;MEK1 antibody;MEKK1 antibody;Mitogen activated protein kinase kinase 1 antibody;Mitogen activated protein kinase kinase 2 antibody;Mitogen-activated protein kinase kinase 2, p45 antibody;MK2 antibody;MKK 1 antibody;MKK 2 antibody;MKK1 antibody;MKK2 antibody;MP2K1_HUMAN antibody;PRKMK 1 antibody;PRKMK 2 antibody;Prkmk1 antibody;Prkmk2 antibody;protein kinase, mitogen-activated, kinase 1 (MAP kinase kinase 1) antibody;Protein kinase, mitogen-activated, kinase 1 antibody;Protein kinase, mitogen-activated, kinase 2 antibody

SEQUENCE SIMILARITIES

Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.

POST-TRANSLATIONAL MODIFICATION

MAPKK is itself dependent on Ser/Thr phosphorylation for activity catalyzed by MAP kinase kinase kinases (RAF or MEKK1). Phosphorylated by MAP2K1/MEK1 (By similarity).; Acetylation of Ser-222 and Ser-226 by Yersinia yopJ prevents phosphorylation and activation, thus blocking the MAPK signaling pathway.

SUBCELLULAR LOCATION

Cytoplasm, Nucleus, Membrane, Mitochondrion

FUNCTION

A family of protein kinases located upstream of the MAP kinases and responsible for their activation has been identified. The prototype member of this family, designated MAP kinase kinase, or MEK-1, specifically phosphorylates the MAP kinase regulatory threonine and tyrosine residues present in the Thr-Glu-Tyr motif of ERK. A second MEK family member, MEK-2, resembles MEK-1 in its substrate specificity. MEK-3 (or MKK-3) functions to activate p38 MAP kinase, and MEK-4 (also called SEK1 or MKK-4) activates both p38 and JNK MAP kinases. MEK-5 appears to specifically phosphorylate ERK5, whereas MEK-6 phosphorylates p38 and p38b. MEK-7 (or MKK-7) phosphorylates and activates the JNK signal transduction pathway.