Albumin Recombinant Rabbit Monoclonal Antibody - BSA and Azide free [JF32-10] (HA750352)

UNIPROT #

P02768

PROTEIN NAME

Albumin

SYNONYMS

alb antibody;ALBU_HUMAN antibody;Albumin (32 AA) antibody;Albumin (AA 34) antibody;cell growth inhibiting protein 42 antibody;DKFZp779N1935 antibody;GIG20 antibody;GIG42 antibody;growth-inhibiting protein 20 antibody;OTTHUMP00000220436 antibody;OTTHUMP00000220438 antibody;OTTHUMP00000220439 antibody;PRO0883 antibody;PRO0903 antibody;PRO1341 antibody;PRO1708 antibody;PRO2044 antibody;PRO2619 antibody;PRO2675 antibody;Serum albumin antibody;UNQ696/PRO1341 antibody

SEQUENCE SIMILARITIES

Belongs to the ALB/AFP/VDB family.

TISSUE SPECIFICITY

Plasma.

POST-TRANSLATIONAL MODIFICATION

Kenitra variant is partially O-glycosylated at Thr-620. It has two new disulfide bonds Cys-600 to Cys-602 and Cys-601 to Cys-606.; Glycated in diabetic patients.; Phosphorylated by FAM20C in the extracellular medium.; Acetylated on Lys-223 by acetylsalicylic acid.

SUBCELLULAR LOCATION

Secreted.

FUNCTION

Serum albumin (ALB), the main protein in plasma, has a very good binding capacity for water, fatty acids, calcium, sodium, bilirubin, hormones, potassium and drugs. The primary function of ALB is to regulate the colloidal osmotic pressure of blood. Albumin is synthesized in the liver as preproalbumin, which has an N-terminal peptide that is removed before the nascent protein is released from the rough endoplasmic reticulum. The product, proalbumin, is in turn cleaved in the Golgi vesicles to produce the secreted form of albumin. Mutations in the ALB gene may result in familial dysalbuminemic hyperthyroxinemia (FDH), a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T4. FDH is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian populations.