FGF18 Recombinant Rabbit Monoclonal Antibody [PSH01-24] - BSA and Azide free
Catalog# HA750700
FGF18 Recombinant Rabbit Monoclonal Antibody [PSH01-24] - BSA and Azide free
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WB
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Human
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Mouse
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unconjugated
Overview
Product Name
FGF18 Recombinant Rabbit Monoclonal Antibody [PSH01-24] - BSA and Azide free
Antibody Type
Recombinant Rabbit monoclonal Antibody
Immunogen
Recombinant protein within mouse FGF18 aa 1-207 / 207.
Species Reactivity
Human, Mouse
Validated Applications
WB
Target Molecular Weight
Predicted band size: 24 kDa
Conjugation
unconjugated
Clone Number
PSH01-24
Product Features
Form
Liquid
Concentration
1mg/ml
Storage Instructions
Store at 2-8℃. Avoid freeze.
Storage Buffer
1*PBS (pH7.4).
Isotype
IgG
Purification Method
Protein A affinity purified.
Application Dilution
Target
Function
Fibroblast growth factor 18 (FGF-18) is a protein that is encoded by the FGF18 gene in humans. The protein was first discovered in 1998, when two newly-identified murine genes Fgf17 and Fgf18 were described and confirmed as being closely related by sequence homology to Fgf8. The three proteins were eventually grouped into the FGF8 subfamily, which contains several of the endocrine FGF superfamily members FGF8, FGF17, and FGF18. Subsequent studies identified FGF18's role in promoting chondrogenesis, and an apparent specific activity for the generation of the hyaline cartilage in articular joints. The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, and tissue repair. It has been shown in vitro that this protein is able to induce the outgrowth of neurites in PC12 cells.
Background References
1. Guo K et al. HDAC7 promotes NSCLC proliferation and metastasis via stabilization by deubiquitinase USP10 and activation of β-catenin-FGF18 pathway. J Exp Clin Cancer Res. 2022 Mar
2. Yue M et al. Tissue-specific analysis of Fgf18 gene function in palate development. Dev Dyn. 2021 Apr
Subcellular Location
Secreted.
Synonyms
FGF 18 antibody
FGF-18 antibody
Fgf18 antibody
FGF18_HUMAN antibody
FGFI antibody
Fibroblast growth factor 18 antibody
zFGF5 antibody
Images
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☑ Cell treatment (CT)
This data was developed using HA721641, the same antibody clone in a different buffer formulation.
Western blot analysis of FGF18 on different lysates with Rabbit anti-FGF18 antibody (HA721641) at 1/1,000 dilution.
Lane 1: 293T whole cell lysate
Lane 2: 293T overexpress mouse FGF18 whole cell lysate
Lane 3: 293T overexpress human FGF18 whole cell lysate
Lysates/proteins at 20 µg/Lane.
Predicted band size: 24 kDa
Observed band size: 24 kDa
Exposure time: 2 minutes;
4-20% SDS-PAGE gel.
Proteins were transferred to a PVDF membrane and blocked with 5% NFDM/TBST for 1 hour at room temperature. The primary antibody (HA721641) at 1/1,000 dilution was used in 5% NFDM/TBST at room temperature for 2 hours. Goat Anti-Rabbit IgG - HRP Secondary Antibody (HA1001) at 1:100,000 dilution was used for 1 hour at room temperature.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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