FGF18 Recombinant Rabbit Monoclonal Antibody [PSH01-24]
Catalog# HA721641
FGF18 Recombinant Rabbit Monoclonal Antibody [PSH01-24]
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WB
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Human
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Mouse
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HA750700
不含抗保成分
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unconjugated
Overview
Product Name
FGF18 Recombinant Rabbit Monoclonal Antibody [PSH01-24]
Antibody Type
Recombinant Rabbit monoclonal Antibody
Immunogen
Recombinant protein within mouse FGF18 aa 1-207 / 207.
Species Reactivity
Human, Mouse
Validated Applications
WB
Molecular Weight
Predicted band size: 24 kDa
Conjugation
unconjugated
Clone Number
PSH01-24
RRID
Reactivity Data
| WB | |
|---|---|
| Human |
|
| Mouse |
|
Product Features
Form
Liquid
Concentration
Storage Instructions
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). Store at -20℃ long term.
Storage Buffer
PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Isotype
IgG
Purification Method
Protein A affinity purified.
Application Dilution
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WB
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1:1,000
Target
Function
Fibroblast growth factor 18 is a protein that in humans is encoded by the FGF18 gene. The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. It has been shown in vitro that this protein is able to induce neurite outgrowth in PC12 cells. FGF18 signals through fibroblast growth factor receptor FGFR3 to promote chondrogenesis and has been shown to cause thickening of cartilage in a murine model of osteoarthritis, and the recombinant version of it (sprifermin) is in clinical trial as a potential treatment for osteoarthritis. Studies of the similar proteins in mouse and chick suggested that this protein is a pleiotropic growth factor that stimulates proliferation in a number of tissues, most notably the liver and small intestine. Knockout studies of the similar gene in mice implied the role of this protein in regulating proliferation and differentiation of midline cerebellar structures.
Background References
1. Guo K et al. HDAC7 promotes NSCLC proliferation and metastasis via stabilization by deubiquitinase USP10 and activation of β-catenin-FGF18 pathway. J Exp Clin Cancer Res. 2022 Mar
2. Yue M et al. Tissue-specific analysis of Fgf18 gene function in palate development. Dev Dyn. 2021 Apr
Subcellular Location
Secreted.
Synonyms
FGF 18 antibody
FGF-18 antibody
Fgf18 antibody
FGF18_HUMAN antibody
FGFI antibody
Fibroblast growth factor 18 antibody
zFGF5 antibody
Images
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☑ Cell treatment (CT)
Western blot analysis of FGF18 on different lysates with Rabbit anti-FGF18 antibody (HA721641) at 1/1,000 dilution.
Lane 1: 293T whole cell lysate
Lane 2: 293T overexpress mouse FGF18 whole cell lysate
Lane 3: 293T overexpress human FGF18 whole cell lysate
Lysates/proteins at 20 µg/Lane.
Predicted band size: 24 kDa
Observed band size: 24 kDa
Exposure time: 2 minutes;
4-20% SDS-PAGE gel.
Proteins were transferred to a PVDF membrane and blocked with 5% NFDM/TBST for 1 hour at room temperature. The primary antibody (HA721641) at 1/1,000 dilution was used in 5% NFDM/TBST at room temperature for 2 hours. Goat Anti-Rabbit IgG - HRP Secondary Antibody (HA1001) at 1:100,000 dilution was used for 1 hour at room temperature.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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