ADAMTS5 Recombinant Rabbit Monoclonal Antibody - BSA and Azide free [PSH03-52] (HA750886)

UNIPROT #

Q9UNA0

PROTEIN NAME

ADAMTS5

SYNONYMS

A disintegrin and metalloproteinase with thrombospondin motifs 11 antibody;A disintegrin and metalloproteinase with thrombospondin motifs 5 antibody;A disintegrin like and metalloprotease (reprolysin type) with thrombospondin type 1 motif 5 antibody;A disintegrin like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase 2) antibody;A disintegrin-like and metalloprotease with thrombospondin type 1 motif, 5 antibody;A Disintigrin And Metalloproteinase with ThromboSpondin motif-5 antibody;ADAM metallopeptidase with thrombospondin type 1 motif 5 antibody;ADAM TS 11 antibody;ADAM TS 5 antibody;ADAM TS5 antibody;ADAM-TS 11 antibody;ADAM-TS 5 antibody;ADAM-TS5 antibody;ADAMTS 11 antibody;ADAMTS 5 antibody;ADAMTS-11 antibody;ADAMTS-5 antibody;ADAMTS11 antibody;ADAMTS11, formerly antibody;Adamts5 antibody;ADMP 2 antibody;ADMP-2 antibody;ADMP2 antibody;Aggrecanase 2 antibody;Aggrecanase-2 antibody;ATS5_HUMAN antibody;FLJ36738 antibody;Implantin antibody;ThromboSpondin motif-5 antibody

SUBCELLULAR LOCATION

Secreted, extracellular space, extracellular matrix.

FUNCTION

A disintegrin and metalloproteinase with thrombospondin motifs 5 also known as ADAMTS5 is an enzyme that in humans is encoded by the ADAMTS5 gene. ADAMTS5 is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs and functions as aggrecanase to cleave aggrecan, a major proteoglycan of cartilage. ADAMTS5 may also have a role in the pathogenesis of human osteoarthritis.