DR3 / LARD Recombinant Rabbit Monoclonal Antibody - BSA and Azide free [PSH13-90] (HA751492)

UNIPROT #

Q93038

PROTEIN NAME

DR3 / LARD

SYNONYMS

Apo 3 antibody;Apo-3 antibody;Apo3 antibody;Apoptosis inducing receptor AIR antibody;Apoptosis inducing receptor antibody;Apoptosis mediating receptor antibody;Apoptosis mediating receptor DR 3 antibody;Apoptosis mediating receptor DR3 antibody;Apoptosis mediating receptor TRAMP antibody;Apoptosis-inducing receptor AIR antibody;Apoptosis-mediating receptor DR3 antibody;Apoptosis-mediating receptor TRAMP antibody;DDR 3 antibody;DDR3 antibody;Death domain receptor 3 antibody;Death domain receptor 3 soluble form antibody;Death receptor 3 antibody;Death receptor beta antibody;DR 3 antibody;DR3 antibody;LARD antibody;Lymphocyte associated receptor of death antibody;Lymphocyte-associated receptor of death antibody;Protein WSL antibody;Protein WSL-1 antibody;TNF receptor superfamily member 25 antibody;TNFR25 antibody;TNFRSF 12 antibody;TNFRSF 25 antibody;TNFRSF12 antibody;TNFRSF12, formerly antibody;TNFRSF25 antibody;TNR25_HUMAN antibody;TR 3 antibody;TR3 antibody;TRAMP antibody;Translocating chain association membrane protein antibody;Tumor necrosis factor receptor superfamily member 12 antibody;Tumor necrosis factor receptor superfamily member 25 antibody;Tumor necrosis factor receptor superfamily, member 12 (translocating chain association membrane protein) antibody;Tumor necrosis factor receptor superfamily, member 12, formerly antibody;WSL 1 antibody;WSL antibody;WSL LR antibody;WSL protein antibody;WSL1 antibody;WSL1 protein antibody;WSLLR antibody

SUBCELLULAR LOCATION

Cell membrane; Secreted.

FUNCTION

Death receptor 3 (DR3), also known as tumor necrosis factor receptor superfamily member 25 (TNFRSF25), is a cell surface receptor of the tumor necrosis factor receptor superfamily which mediates apoptotic signalling and differentiation. Its only known TNFSF ligand is TNF-like protein 1A (TL1A). The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed preferentially by activated and antigen-experienced T lymphocytes. TNFRSF25 is also highly expressed by FoxP3 positive regulatory T lymphocytes. TNFRSF25 is activated by a monogamous ligand, known as TL1A (TNFSF15), which is rapidly upregulated in antigen presenting cells and some endothelial cells following Toll-Like Receptor or Fc receptor activation. This receptor has been shown to signal both through the TRADD adaptor molecule to stimulate NF-kappa B activity or through the FADD adaptor molecule to stimulate caspase activation and regulate cell apoptosis.