Prosurfactant Protein C Recombinant Rabbit Monoclonal Antibody - BSA and Azide free [PSH15-28] (HA751550)

UNIPROT #

P11686

PROTEIN NAME

Prosurfactant Protein C

SYNONYMS

BRICD6 antibody;BRICHOS domain containing 6 antibody;PSP C antibody;PSPC antibody;PSPC_HUMAN antibody;Pulmonary surfactant apoprotein 2 antibody;Pulmonary surfactant apoprotein PSP C antibody;pulmonary surfactant apoprotein-2 SP-C antibody;Pulmonary surfactant associated protein C antibody;Pulmonary surfactant associated proteolipid SPL pVal antibody;Pulmonary surfactant associated proteolipid SPL(Val) antibody;Pulmonary surfactant protein SP5 antibody;Pulmonary surfactant-associated protein C antibody;Pulmonary surfactant-associated proteolipid SPL(Val) antibody;SFTP 2 antibody;SFTP2 antibody;SFTPC antibody;SFTPC surfactant pulmonary associated protein C antibody;SMDP2 antibody;SP 5 antibody;SP C antibody;SP-C antibody;SP5 antibody;SPC antibody;Surfactant associated protein pulmonary 2 antibody;Surfactant protein c antibody;Surfactant proteolipid SPL-pVal antibody;Surfactant pulmonary associated protein C antibody

SUBCELLULAR LOCATION

Secreted, extracellular space, surface film.

FUNCTION

Surfactant protein C (SP-C), is one of the pulmonary surfactant proteins. In humans this is encoded by the SFTPC gene. It is a membrane protein. SFTPC is a 197-residue protein made up of two halves: a unique N-terminal propeptide domain and a C-terminal BRICHOS domain. The around 100-aa long propeptide domain actually contains not only the cleaved part, but also the mature peptide. The propeptide of pulmonary surfactant C has an N-terminal alpha-helical segment whose suggested function was stabilization of the protein structure, since the mature peptide can irreversibly transform from its native alpha-helical structure to beta-sheet aggregates and form amyloid fibrils. The correct intracellular trafficking of proSP-C has also been reported to depend on the propeptide. The structure of the BRICHOS domain has been solved. Mutations in this domain also lead to amyloid fibrils made up of the mature peptide, suggesting a chaperone activity.