Human IL-6 Recombinant Rabbit Monoclonal Antibody [PS00-15] - BSA and Azide free (Detector)

Function

Interleukin 6 (IL-6) is an interleukin that acts as both a pro-inflammatory cytokine and an anti-inflammatory myokine. In addition, osteoblasts secrete IL-6 to stimulate osteoclast formation. Smooth muscle cells in the tunica media of many blood vessels also produce IL-6 as a pro-inflammatory cytokine. IL-6's role as an anti-inflammatory myokine is mediated through its inhibitory effects on TNF-alpha and IL-1 and its activation of IL-1ra and IL-10. There is some early evidence that IL-6 can be used as an inflammatory marker for severe COVID-19 infection with poor prognosis, in the context of the wider coronavirus pandemic. IL-6 is secreted by macrophages in response to specific microbial molecules, referred to as pathogen-associated molecular patterns (PAMPs). These PAMPs bind to an important group of detection molecules of the innate immune system, called pattern recognition receptors (PRRs), including Toll-like receptors (TLRs). These are present on the cell surface and intracellular compartments and induce intracellular signaling cascades that give rise to inflammatory cytokine production. IL-6 is an important mediator of fever and of the acute phase response. IL-6 stimulates the inflammatory and auto-immune processes in many diseases such as multiple sclerosis, neuromyelitis optica spectrum disorder (NMOSD), diabetes, atherosclerosis, depression, Alzheimer's disease, systemic lupus erythematosus, multiple myeloma, prostate cancer, Behçet's disease, rheumatoid arthritis, and intracerebral hemorrhage. The Capture Antibody (HA721167) supplied in an unconjugated format and it is suitable for sandwich ELISAs to quantify Human IL-6. The recommended pair for sandwich ELISA is Detection Antibody (HA721168). The reference range value is 5 - 1000 pg/ml for human IL-6.

Background References

1. Kang S., Tanaka T., Narazaki M., Kishimoto T. Targeting Interleukin-6 Signaling in Clinic. Immunity 50:1007-1023(2019).

2. Wolsk E., Mygind H., Groendahl T.S., Pedersen B.K., van Hall G. IL-6 selectively stimulates fat metabolism in human skeletal muscle. Am. J. Physiol. 299:E832-E840(2010)

Subcellular Location

Extracellular region or secreted.

UNIPROT

SwissProt: P05231 Human

Entrez Gene: 3569 Human

Unigene: 654458 Human

Synonyms