HLA-DQA1 Recombinant Rabbit Monoclonal Antibody
Catalog# IRS035
HLA-DQA1 Recombinant Rabbit Monoclonal Antibody
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mIHC
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Human
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unconjugated
Overview
Product Name
HLA-DQA1 Recombinant Rabbit Monoclonal Antibody
Antibody Type
Recombinant Rabbit monoclonal Antibody
Immunogen
Synthetic peptide within Human HLA-DQA1 aa 205-254 / 254.
Species Reactivity
Human
Validated Applications
mIHC
Molecular Weight
Predicted band size: 28 kDa
Positive Control
Human tonsils tissue.
Conjugation
unconjugated
Product Features
Form
Liquid
Concentration
(The concentration of this product may be batch-dependent)
Storage Instructions
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). Store at -20℃ long term.
Storage Buffer
PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Isotype
IgG
Purification Method
Protein A affinity purified.
Application Dilution
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mIHC
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1:100
Target
Function
Major histocompatibility complex, class II, DQ alpha 1, also known as HLA-DQA1, is a human gene present on short arm of chromosome 6 (6p21.3) and also denotes the genetic locus which contains this gene. The protein encoded by this gene is one of two proteins that are required to form the DQ heterodimer, a cell surface receptor essential to the function of the immune system.HLA-DQA1 belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen-presenting cells.
Background References
1. Schmidt H et al. HLA-DR15 haplotype and multiple sclerosis: a HuGE review. Am. J. Epidemiol 165 (10): 1097-109 (2007).
2. Han R et al. Analysis of the nucleotide sequence variation of the antigen-binding domain of DR alpha and DQ alpha molecules as related to the evolution of papillomavirus-induced warts in rabbits. J Invest Dermatol 103(3):376-80 (1994).
Sequence Similarity
Belongs to the MHC class II family.
Subcellular Location
Cell membrane. Endoplasmic reticulum membrane.
UNIPROT
Synonyms
CD antibody
CELIAC1 antibody
DC 1 alpha chain antibody
DC alpha antibody
DC-1 alpha chain antibody
DC-alpha antibody
DC1, included antibody
DQ alpha 1 chain antibody
DQ-A1 antibody
DQ-DRW9 alpha chain antibody
ExpandImages
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mIHC analysis of human tonsils tissue (Formalin/PFA-fixed paraffin-embedded sections) with Rabbit anti-HLA-DQA1 antibody (IRS035) at 1/100 dilution. The immunostaining was performed with the IRISKitCmTSA Kit (900808). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 30 mins at 95℃. DAPI (blue) was used as a nuclear counter stain. Image acquisition was performed with Olympus VS200 Slide Scanner.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
Products with the same target and pathway
HLA-DQA1 Recombinant Rabbit Monoclonal Antibody [JU17-34]
Application: WB,IHC-P,IP,IF-Cell,mIHC,IF-Tissue,FC
Reactivity: Human,Mouse,Rat
Conjugate: unconjugated
