RAGE Recombinant Rabbit Monoclonal Antibody

Function

Advanced glycosylation end products of proteins (AGEs) are nonenzymatically glycosylated proteins that are associated with a variety of conditions, including diabetes and other vascular disorders, as well as amyloidosis. These proteins regulate cellular functions via specific cell surface acceptor molecules, such as RAGE (receptor for advanced glycosylation end products). RAGE is a type 1 membrane protein that is found on the surface of endothelial cells, mononuclear phagocytes and vascular smooth muscle cells. Binding of AGEs to RAGE results in the induction of cellular oxidant stress and activation of the transcription factor NFkB. Evidence suggests that the induction of oxidant stress results in the activation of an intracellular cascade involving p21 ras and MAP kinase, which leads to activation of transcription.

Background References

1. Kim J et al. Cytoplasmic translocation of high-mobility group box-1 protein is induced by diabetes and high glucose in retinal pericytes. Mol Med Rep 14:3655-61 (2016).

2. Yao X et al. Mitochondrial ROS Induces Cardiac Inflammation via a Pathway through mtDNA Damage in a Pneumonia-Related Sepsis Model. PLoS One 10:e0139416 (2015).

Tissue Specificity

Isoform 1: Expressed at higher levels in the coronary arterioles in type 2 diabetic mice (at protein level). Endothelial cells. Expressed in lung, kidney, brain and heart. Most prevalent isoform with the highest level in heart. Isoform 2: Expressed in brain, lung, kidney and small intestine with the highest level in lung. Expressed in brain, lung, kidney and small intestine with the highest level in small intestine (at protein level). Detected in neurons of the cerebrum, bronchial epithelium, endothelial cells, tubular cells of kidney and epithelial cells of small intestine (at protein level). Expression is increased in the kidney of diabetic wild-type mice (at protein level), but not in the other tissues. Expressed only in kidney. Expression is increased in the kidney of diabetic mice. Isoform 3: Expressed in lung, kidney and heart. The second most prevalent isoform with the highest level in lung. Not expressed in brain. Isoform 4: Expressed at very low level in lung only. Isoform 5: Expressed at very low level in lung only. Isoform 6: Expressed at very low level in lung only. Isoform 7: Expressed at very low level in heart only. Isoform 8: Expressed at very low level in lung only. Isoform 9: Expressed at very low level in heart only. Isoform 10: Expressed in lung, brain, heart and kidney with a very high level in kidney. Isoform 11: Expressed in brain, kidney and heart. Not expressed in lung. Isoform 12: Expressed at very low level in lung and kidney. Isoform 13: Expressed at very low level in lung only.

Subcellular Location

Cell membrane, Secreted.

UNIPROT

SwissProt: Q62151 Mouse

Synonyms

Advanced glycosylation end product-specific receptor antibody

Ager antibody

MGC2235 antibody

RAGE_HUMAN antibody

Receptor for advanced glycosylation end products antibody