Calbindin Recombinant Rabbit Monoclonal Antibody
Catalog# IRS098RB
Calbindin Recombinant Rabbit Monoclonal Antibody
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mIHC
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Human
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unconjugated
Overview
Product Name
Calbindin Recombinant Rabbit Monoclonal Antibody
Antibody Type
Recombinant Rabbit monoclonal Antibody
Immunogen
Synthetic peptide within Human Calbindin aa 51-100 / 261.
Species Reactivity
Human
Validated Applications
mIHC
Molecular Weight
Predicted band size: 30 kDa
Positive Control
Human kidney tissue.
Conjugation
unconjugated
Product Features
Form
Liquid
Concentration
Storage Instructions
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). Store at -20℃ long term.
Storage Buffer
1*PBS (pH7.4), 0.1% BSA, 40% Glycerol, 0.2% Proclean 950.
Isotype
IgG
Purification Method
Protein A affinity purified.
Application Dilution
-
mIHC
-
1:100
Target
Function
Calbindin 1 is a protein that in humans is encoded by the CALB1 gene. It belongs to the calbindin family of calcium-binding proteins, along with calretinin (CALB2). The protein encoded by this gene is a member of the calcium-binding protein superfamily that includes calmodulin and troponin C. Originally described as a 27 kDa protein, it is now known to be a 28 kDa protein. It contains four active calcium-binding domains, and has two modified domains that are thought to have lost their calcium binding capability. This protein is thought to buffer entry of calcium upon stimulation of glutamate receptors. Depletion of this protein was noted in patients with Huntington disease.
Background References
1. Noble JW et al. Exploring Calbindin-IMPase fusion proteins structure and activity. Biochem Biophys Rep. 2022 May
2. Attig J et al. Human endogenous retrovirus onco-exaptation counters cancer cell senescence through calbindin. J Clin Invest. 2023 Jul
Subcellular Location
Cytosol, Nucleus.
UNIPROT
Synonyms
avian-type antibody
CAB27 antibody
CALB 1 antibody
CALB antibody
CALB1 antibody
CALB1_HUMAN antibody
Calbindin 1 28kDa antibody
Calbindin antibody
Calbindin D28 antibody
D 28K antibody
ExpandImages
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mIHC analysis of human kidney tissue (Formalin/PFA-fixed paraffin-embedded sections) with Rabbit anti-Calbindin antibody (IRS098RB) at 1/100 dilution. The immunostaining was performed with the IRISKitCmTSA Kit (900808). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 30 mins at 95℃. DAPI (blue) was used as a nuclear counter stain. Image acquisition was performed with Olympus VS200 Slide Scanner.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"