Syndecan 1 Recombinant Monoclonal Antibody

Function

Syndecan-1 (SYND1), also designated CD138, is a type I integral membrane proteoglycan that contains both chondroitin sulfate and heparan sulfate groups. It is expressed in mouse on pre-B cells, immature B cells and plasma cells. Syndecan-1 is also found on the basolateral surfaces of epithelial cells, endothelial cells of sprouting capillaries and embryonic condensing mesenchymal cells. Syndecan-1 functions as an extracellular matrix receptor which binds to collagens, Fibronectin and Thrombospondin. It has been shown to co-localize with Actin-rich filaments and may act to link the cytoskeleton to the extracellular matrix.

Background References

1. V h tupa M et al. Lack of R-Ras Leads to Increased Vascular Permeability in Ischemic Retinopathy. Invest Ophthalmol Vis Sci 57:4898-4909 (2016).

2. Miyake M et al. Clinical implications in the shift of syndecan-1 expression from the cell membrane to the cytoplasm in bladder cancer. BMC Cancer 14:86 (2014).

Subcellular Location

Membrane, Secreted.

UNIPROT

SwissProt: P18827 Human

Synonyms