CD1c Recombinant Monoclonal Antibody
Catalog# IRS111RB
CD1c Recombinant Monoclonal Antibody
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mIHC
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Human
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unconjugated
Overview
Product Name
CD1c Recombinant Monoclonal Antibody
Antibody Type
Recombinant Rabbit monoclonal Antibody
Immunogen
Synthetic peptide within human CD1c aa 71-120 / 333.
Species Reactivity
Human
Validated Applications
mIHC
Molecular Weight
Predicted band size: 38 kDa
Positive Control
Human tonsil tissue.
Conjugation
unconjugated
Product Features
Form
Liquid
Concentration
Storage Instructions
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). Store at -20℃ long term.
Storage Buffer
1*PBS (pH7.4), 0.1% BSA, 40% Glycerol, 0.2% Proclean 950.
Isotype
IgG
Purification Method
Protein A affinity purified.
Application Dilution
-
mIHC
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1:100
Target
Function
This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene is broadly distributed throughout the endocytic system via a tyrosine-based motif in the cytoplasmic tail. Alternatively spliced transcript variants of this gene have been observed, but their full-length nature is not known.
Background References
1. Bourdely P et al. Transcriptional and Functional Analysis of CD1c(+) Human Dendritic Cells Identifies a CD163(+) Subset Priming CD8(+)CD103(+) T Cells. Immunity. 2020 Aug
2. Chen X et al. CD1C is associated with breast cancer prognosis and immune infiltrates. BMC Cancer. 2023 Feb
Subcellular Location
Cell membrane, Endosome membrane, Lysosome.
UNIPROT
Synonyms
BDCA1 antibody
CD1 antibody
CD1A antibody
CD1c antibody
CD1c antigen antibody
CD1C antigen c polypeptide antibody
CD1c molecule antibody
CD1C_HUMAN antibody
Cortical thymocyte antigen CD1C antibody
Differentiation antigen CD1 alpha 3 antibody
ExpandImages
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mIHC analysis of human tonsil tissue (Formalin/PFA-fixed paraffin-embedded sections) with Rabbit anti-CD1c antibody (IRS111RB) at 1/100 dilution. The immunostaining was performed with the IRISKitCmTSA Kit (900808). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 30 mins at 95℃. DAPI (blue) was used as a nuclear counter stain. Image acquisition was performed with Olympus VS200 Slide Scanner.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"