Fast Myosin Skeletal Heavy chain Recombinant Rabbit Monoclonal Antibody

Function

Myosin-1, also known as 'striated muscle myosin heavy chain 1', is a protein that in humans is encoded by the MYH1 gene. This gene is most highly expressed in fast type IIX/D muscle fibres of vertebrates and encodes a protein found uniquely in striated muscle; it is a class II myosin with a long coiled coil tail that dimerizes and should not be confused with 'Myosin 1' encoded by the MYO1 family of genes (MYO1A-MYO1H). Class I MYO1 genes function in many cell types throughout biology and are single-headed membrane-binding myosins that lack a long coiled coil tail. Myosin is a major contractile protein that converts chemical energy into mechanical energy through the hydrolysis of ATP. Class II Myosins are hexameric proteins composed of a pair of myosin heavy chains (MYH) and two pairs of nonidentical light chains. Myosin heavy chains are encoded by a multigene family. In mammals, at least ten different myosin heavy chain (MYH) isoforms have been described from striated, smooth, but rarely in non-muscle cells. These isoforms show expression that is spatially and temporally regulated during development.

Background References

1. Alsaif HS et al. MYH1 is a candidate gene for recurrent rhabdomyolysis in humans. Am J Med Genet A. 2021 Jul

2. de Albuquerque AL et al. Prevalence of the E321G MYH1 variant in Brazilian Quarter Horses. Equine Vet J. 2022 Sep

Subcellular Location

Cytoplasm, myofibril.

UNIPROT

SwissProt: Q5SX40 Mouse

Synonyms